UnifiedDoseFinding

0.1.10

Dose-Finding Methods for Non-Binary Outcomes

0packages depend

3.4Kdownloads / year

–test coverage

11/13checks pass

Overview

About

Maintained by Chia-Wei HsuFirst published 2020-07-084 releasesCRAN page ↗

In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a continuous response. This package provides the setup and calculations needed to run a dose-finding trial with non-binary endpoints and performs simulations to assess design’s operating characteristics under various scenarios. Three dose finding designs are included in this package: unified phase I design (Ivanova et al. (2009) doi:10.1111/j.1541-0420.2008.01045.x), Quasi-CRM/Robust-Quasi-CRM (Yuan et al. (2007) doi:10.1111/j.1541-0420.2006.00666.x, Pan et al. (2014) doi:10.1371/journal.pone.0098147) and generalized BOIN design (Mu et al. (2018) doi:10.1111/rssc.12263). The toxicity endpoints can be handled with these functions including equivalent toxicity score (ETS), total toxicity burden (TTB), general continuous toxicity endpoints, with incorporating ordinal grade toxicity information into dose-finding procedure. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous toxicity score, and incorporate safety and/or stopping rules.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("UnifiedDoseFinding", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-unifieddosefinding

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-UnifiedDoseFinding

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-UnifiedDoseFinding

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

2NOTE11OK

Failing flavors

NOTE r-devel-linux-x86_64-debian-clang
NOTE r-devel-linux-x86_64-debian-gcc

Slowest check: 1.1 min · r-devel-linux-x86_64-fedora-clang

Code health

None

Tests · ratio 0.00

not tracked

Coverage

100%

Documentation · exports

None

Vignettes

README

Dependencies · direct

Check history

NOTE2026-03-10
12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Downloads

3.4K

CRAN downloads in the past year

Rank #13,093 · ~9/day · ~284/mo

By source Releases R versions

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29130 days

81990 days

3.4K1 year

Compare downloads with other packages →

Also on96 r2u12 autocran34 c2d4u

Dependencies

Declared dependencies

0 external dependencies (excludes base and recommended)

Depends (0)

none

Imports (0)

none

LinkingTo (0)

none

Suggests (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

Code Composition

R 1,821 (60%)Rd 1,200 (40%)

Code characteristics

Cyclomatic complexity: 9.5 median / 33 max
Documented parameters: 100%

Test coverage

Line coverage

–

Expression

–

Tests / Examples

–

Functions

28 18 exported

Complexity

12 avg / 33 max

Call network

28 nodes / 13 edges

Test coverage has not been measured for this package yet; nodes fall back to a neutral fill.

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Lowest coverage

Per-function coverage is not measured for this package yet.

People & History

People (0)

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Release timeline

4 releases. Pick two to compare their code metrics. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
R
R 4.4.0 released · 2024-04-24
R
R 4.3.0 released · 2023-04-21
0.1.10Latest
2022-10-16 · current release · diff ↗
R
R 4.2.0 released · 2022-04-22
0.1.9
2022-02-03 · diff ↗
0.1.8
2021-06-04 · diff ↗
R
R 4.1.0 released · 2021-05-18
0.1.7
2020-07-08
R
R 4.0.0 released · 2020-04-24

Package metadata

First published: 2020-07-08
Total releases: 4 / 6 yrs
License: GPL-2 OSI
Download size: 20 KB
Installed size: not tracked yet
With dependencies: not tracked yet