R Observatory: Metrics for UnifiedDoseFinding version 0.1.10

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

UnifiedDoseFinding

0.1.10Package record

Dose-Finding Methods for Non-Binary Outcomes

0packages depend

3.2Kdownloads / year

–test coverage

11/13flavors OK

Overview

About

Maintained by Chia-Wei HsuCRAN page ↗

In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a continuous response. This package provides the setup and calculations needed to run a dose-finding trial with non-binary endpoints and performs simulations to assess design’s operating characteristics under various scenarios. Three dose finding designs are included in this package: unified phase I design (Ivanova et al. (2009) doi:10.1111/j.1541-0420.2008.01045.x), Quasi-CRM/Robust-Quasi-CRM (Yuan et al. (2007) doi:10.1111/j.1541-0420.2006.00666.x, Pan et al. (2014) doi:10.1371/journal.pone.0098147) and generalized BOIN design (Mu et al. (2018) doi:10.1111/rssc.12263). The toxicity endpoints can be handled with these functions including equivalent toxicity score (ETS), total toxicity burden (TTB), general continuous toxicity endpoints, with incorporating ordinal grade toxicity information into dose-finding procedure. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous toxicity score, and incorporate safety and/or stopping rules.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("UnifiedDoseFinding", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-unifieddosefinding

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled. We list this channel from recorded r2u download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-UnifiedDoseFinding

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-UnifiedDoseFinding

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed). We list this channel from recorded autoCRAN download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

Health

CRAN checks

2NOTE11OK

Check messages

NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc

Maintainer: ‘Chia-Wei Hsu <Chia-Wei.Hsu@stjude.org>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Chia-Wei",
                      family = "Hsu",
                      role = c("aut", "cre"),
                      email = "chia-wei.hsu@stjude.org"),
               person(given = "Haitao",
                      family = "Pan",
                      role = "aut"),
               person(given = "Rongji",
                      family = "Mu",
                      role = "aut"))
as necessary.

CRAN check page ↗

Slowest check: 1.0 min · r-release-windows-x86_64

Status changes

NOTE11 OK, 2 NOTENow
NOTE12 OK, 2 NOTE2026-03-10

Advisories

none known

How this is measured·How advisories are found

Documentation

In release 0.1.10

READMENoVignettesNoNEWSNoCitation fileNoWebsitenot declared in DESCRIPTION

Help pages: 18
Examples that run: 100%18 run in a plain check
Exported functions with examples: 100%
Documented parameters: 100%
Return-value docs: 100%
Help pages citing references: 100%

How these are measured

Downloads

3.2K

CRAN downloads in the past year

Rank #18,611 · ~9/day · ~266/mo

Releases R versions

Daily download trend is not available in this view yet.

26030 days

70190 days

3.2K1 year

Compare downloads with other packages →

Also on92 r2u6 autocran57 c2d4u

How downloads are counted

Dependencies

Declared dependencies

0 external dependencies (excludes base and recommended)

Installing UnifiedDoseFinding adds no packages beyond those that come with R.

Depends (0)

none

Imports (0)

none

LinkingTo (0)

none

Suggests (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

How these are counted

Code & Tests

People & History

People (from the free-text Author field) (3)

Chia-Wei Hsu

Haitao Pan

Rongji Mu

Maintainer since 0.1.7 (2020)

Releases (4)

Pick two releases to compare their code metrics.

R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
R
R 4.4.0 released · 2024-04-24
R
R 4.3.0 released · 2023-04-21
0.1.10Latest
record
2022-10-16 · current release · diff ↗
R
R 4.2.0 released · 2022-04-22
0.1.9
record
2022-02-03 · diff ↗ ·
removed 5 exports
get_oc_gBOIN_Continuous, next_gBOIN_Continuous, select_mtd_gBOIN_Continuous, select_Ivanova_binary, select_Ivanova_continuous

added 5 exports
get_oc_gBOIN_continuous, next_gBOIN_continuous, select_mtd_gBOIN_continuous, select_mtd_Ivanova_binary, select_mtd_Ivanova_continuous
0.1.8
record
2021-06-04 · diff ↗ ·
removed 6 exports
next_mtd_gBOIN_Continuous, next_mtd_gBOIN_TB, next_mtd_QuasiBOIN, get_oc_Quasi_CRM, next_mtd_Quasi_CRM, select_mtd_Quasi_CRM

added 6 exports
next_gBOIN_Continuous, next_gBOIN_TB, next_QuasiBOIN, get_oc_RQ_CRM, next_RQ_CRM, select_mtd_RQ_CRM
R
R 4.1.0 released · 2021-05-18
0.1.7
record
2020-07-08
R
R 4.0.0 released · 2020-04-24

Package metadata

First published: 2020-07-08
Total releases: 4 / 6 yrs
License: GPL-2 OSI
Download size: 20 KB

Appears in task views

Clinical Trial Design, Monitoring, Analysis and Reporting Analysis of Pharmacokinetic Data

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("UnifiedDoseFinding")

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for UnifiedDoseFinding version 0.1.10 [Data set]. HJJB, LLC. Data release v2026-10-23. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-23, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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