R Observatory: Metrics for TwoCutoff version 0.1.0

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

TwoCutoff

0.1.0

Deriving Clinically Interpretable Cutoffs for Disease Biomarkers

0packages depend

505downloads / year

0.0%test coverage

13/13checks pass

Overview

About

Maintained by Bhrigu Kumar RajbongshiFirst published 2026-06-241 releasesCRAN page ↗

Provides a reproducible pipeline for deriving two clinically meaningful cutoffs for disease biomarkers using a unified two-stage framework. The package integrates finite mixture modeling with risk prediction using biomarker plus clinical features, followed by decision curve analysis to evaluate clinical utility. Outputs include biomarker density plots, risk calibration curves, decision curves, and summary tables of diagnostic performance. Designed for researchers in bio-statistics, neurology, and data science, this package emphasizes reproducibility, transparency, and clear clinical relevance.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("TwoCutoff", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-twocutoff

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-TwoCutoff

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-TwoCutoff

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 3.8 min · r-oldrel-windows-x86_64

Code health

Yes

Tests · ratio 0.08

0.0%

Coverage · measured lines

100%

Documentation · exports

9

Dependencies · direct

Check history

OK2026-08-05
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-08-01
12 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-06-25
7 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMEYes · 145 wordsVignettesYes · dynamicpkgdown siteNoNEWSYes · 67% structuredCode of conductNoContributing guideNo

Examples that run: 0%
Documented parameters: 98%
Return-value docs: 100%
References docs: 18%

Downloads

505

CRAN downloads in the past year

Rank #21,650 · ~1/day · ~42/mo

Releases R versions

Daily download trend is not available in this view yet.

15930 days

50590 days

5051 year

Compare downloads with other packages →

Also on12 r2u2 autocran

Dependencies

Declared dependencies

12 external dependencies (excludes base and recommended)

Depends (1)

R >= 4.0.0

Imports (9)

dplyr mixtoolsstatspROC xgboost ggplot2 caret patchwork gridExtra

LinkingTo (0)

none

Suggests (4)

rmarkdown DiagrammeR knitr devtools

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

Datasets

People & History

People (3)

Maintainer (1)

Bhrigu Kumar Rajbongshi

Author, Maintainer, Contributor

Authors (3)

Bhrigu Kumar Rajbongshi

Author, Maintainer, Contributor

Nastaran Marzban

Author, Contributor

Seyed Ehsan Saffari

Author, Contributor

Contributors (3)

Bhrigu Kumar Rajbongshi

Author, Maintainer, Contributor

Nastaran Marzban

Author, Contributor

Seyed Ehsan Saffari

Author, Contributor

Package Timeline

1 release. R releases are shown for context.

0.1.0Latest
2026-06-24 · current release
R
R 4.6.0 released · 2026-04-24

Package metadata

First published: 2026-06-24
Total releases: 1 / 1 yrs
License: MIT + file LICENSE OSI
Minimum R: ≥ 4.0.0
Bundled data: 8.9 KB / 1 file
Download size: 726 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("TwoCutoff")

Format

Rajbongshi, B. K., Marzban, N., & Saffari, S. E. (2026). TwoCutoff: Deriving Clinically Interpretable Cutoffs for Disease Biomarkers (Version 0.1.0) [Computer software]. https://doi.org/10.32614/CRAN.package.TwoCutoff

This is what citation() produces when a package has no citation file of its own. If it prints something else, use that.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for TwoCutoff version 0.1.0 [Data set]. HJJB, LLC. Data release v2026-08-18. https://doi.org/10.5281/zenodo.21843040

From data release v2026-08-18, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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