TITEgBOIN

0.4.0

Time-to-Event Dose-Finding Design for Multiple Toxicity Grades

0packages depend

2.6Kdownloads / year

–test coverage

13/13checks pass

Overview

About

Maintained by Jing ZhuFirst published 2023-12-012 releasesCRAN page ↗

In some phase I trials, the design goal is to find the dose associated with a certain target toxicity rate or the dose with a certain weighted sum of rates of various toxicity grades. 'TITEgBOIN' provides the set up and calculations needed to run a dose-finding trial using bayesian optimal interval (BOIN) (Yuan et al. (2016) doi:10.1158/1078-0432.CCR-16-0592), generalized bayesian optimal interval (gBOIN) (Mu et al. (2019) doi:10.1111/rssc.12263), time-to-event bayesian optimal interval (TITEBOIN) (Lin et al. (2020) doi:10.1093/biostatistics/kxz007) and time-to-event generalized bayesian optimal interval (TITEgBOIN) (Takeda et al. (2022) doi:10.1002/pst.2182) designs. 'TITEgBOIN' can conduct tasks: run simulations and get operating characteristics; determine the dose for the next cohort; select maximum tolerated dose (MTD). These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose limiting toxicity (DLT) rates or target normalized equivalent toxicity score (ETS) rates to account for discrete toxicity score, and incorporate safety and/or stopping rules.

Install

R (CRAN)Ubuntu (r2u)openSUSE (OBS)

install.packages("TITEgBOIN", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-titegboin

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-TITEgBOIN

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 46 s · r-devel-windows-x86_64

Check history

OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

Documentation signals are not tracked yet for this package.

Downloads

2.6K

CRAN downloads in the past year

Rank #22,154 · ~7/day · ~220/mo

TITEgBOIN Releases R versions

Daily download trend is not available in this view yet.

11630 days

51890 days

2.6K1 year

Compare downloads with other packages →

Also on94 r2u12 autocran

Dependencies

Declared dependencies

0 external dependencies (excludes base and recommended)

Depends (0)

none

Imports (0)

none

LinkingTo (0)

none

Suggests (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

People & History

People (3)

Maintainer (1)

Jing Zhu

Maintainer, Author

Authors (3)

Jing Zhu

Maintainer, Author

Kentaro Takeda

Author

Jun Zhang

Author

Package Timeline

2 releases. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
0.4.0Latest
2025-02-26 · current release · diff ↗
R
R 4.4.0 released · 2024-04-24
0.3.0
2023-12-01
R
R 4.3.0 released · 2023-04-21

Package metadata

First published: 2023-12-01
Total releases: 2 / 3 yrs
License: GPL-2 OSI
Download size: 16 KB
Installed size: not tracked yet
With dependencies: not tracked yet

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