Selected Events Linked by Evolutionary Conditions in Cancer
Overview
Implements the 'SelectSim' methodology for identifying patterns of co-occurrence and mutual exclusivity between functional genomic alterations in cancer cohorts. The package processes mutation annotation data, constructs alteration matrices, estimates expected alteration-pair frequencies, and quantifies deviations associated with selective interactions. The methodology is described in Iyer et al. (2026) doi:10.1038/s41588-026-02661-4.
- Removed
reshape2dependency; replaced with base R equivalents (tapply,as.data.frame.table). - Fixed
theme_ridges()partial argument match (center→center_axis_labels). - Fixed parallel log file leak in
null_model_parallelusingtempfile()andon.exit(). - Refactored
selectX()to eliminate duplicate verbose/non-verbose code paths. - Added
utils::globalVariables()declarations to suppress R CMD check NOTEs for ggplot2 aesthetics. - Dropped
SystemRequirements: C++14from DESCRIPTION. - Added GitHub community health files:
CONTRIBUTING.md,CODE_OF_CONDUCT.md, issue templates, PR template, and CI workflow. - Expanded test coverage with
test-gam_utils.R. - Repository migrated: development moved from personal branches to CSOgroup/SelectSim;
devbranch merged intomainfor initial public release. - Bumped version to 0.1.6 across all source files
- Updated citation (
inst/CITATION,README) to the published Nature Genetics article: Iyer A, Petrovic M, Sesia D, Nanni L, Mina M, Ciriello G (2026). Evolving patterns of co-mutations from tumor initiation to metastatic progression. *Nature Genetics*. DOI: 10.1038/s41588-026-02661-4
From NEWS.md in the release
Install
Health
- OK13 OK2026-09-08
- ERROR12 OK, 1 ERROR2026-09-07
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-07-29
Show 2 earlier changesHide 2 earlier changes
- ERROR12 OK, 1 ERROR2026-07-27
- OK7 OK2026-07-22
Documentation
- Help pages
- 55
- Examples that run
- 67%37 run in a plain check · 18 only when donttest examples are enabled (R CMD check --as-cran)
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Repository
- PRs merged (all time)
- 86%
- Median days to close, 50 most recently updated closed issues
- 338
- Median days to close, 50 most recently updated closed PRs
- 0
Stars over time
Issues over time
PRs over time
11 development-tooling and community-health practices detected across 4 families in the upstream repository
Checks run against github.com/csogroup/selectsim on 2026-10-25.
The R CMD check workflow runs on Linux, macOS and Windows, and on R-devel
GitHub Pages site last deployed 2026-07-12 · The repository has a site deploy workflow
pkgdown site last built 2026-07-12, before release 0.1.6 (2026-07-21)
Dependencies
Code & Tests
Datasets
People & History
- 0.1.6Latest2026-07-21 · current release
- RR 4.6.0 released · 2026-04-24
Package metadata
- First published
- 2026-07-21
- Total releases
- 1 / 1 yrs
- License
- MIT + file LICENSE OSI
- Minimum R
- ≥ 3.5
- Bundled data
- 2.6 MB / 6 files
- Download size
- 3.6 MB
Cite
Cite this package
Run in R for the authors' entry:
citation("SelectSim")The package provides a citation file, so citation() returns the authors' own entry.
It points to 10.1038/s41588-026-02661-4.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-26, which the citation names so these numbers can be found later. More on citing and the projects behind them.