Population-Level Cell-Cell Communication Analysis Tools
Overview
Facilitates population-level analysis of ligand-receptor (LR) interactions using large-scale single-cell transcriptomic data. Identifies significant LR pairs and quantifies their interactions through correlation-based filtering and projection score computations. Designed for large-sample single-cell studies, the package employs statistical modeling, including linear regression, to investigate LR relationships between cell types. It provides a systematic framework for understanding cell-cell communication, uncovering regulatory interactions and signaling mechanisms. Offers tools for LR pair-level, sample-level, and differential interaction analyses, with comprehensive visualization support to aid biological interpretation. The methodology is described in a manuscript currently under review and will be referenced here once published or publicly available.
Changes in filter_lr_single(), filter_lr_all(), score_lr_single(), single_lr_all(), one_step_single(), one_step_all()
- Added support for average expression matrices. These functions now accept either Seurat objects or average expression matrices (a numeric matrix of gene expression where columns encode cell types and samples, and rows are genes).
- No changes to existing Seurat-based workflows.
From NEWS.md in the release
Install
Health
- OK13 OK2026-09-08
- ERROR12 OK, 1 ERROR2026-09-07
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-09
Show 4 earlier changesHide 4 earlier changes
- ERROR12 OK, 1 ERROR2026-06-08
- OK14 OK2026-04-10
- ERROR13 OK, 1 ERROR2026-04-09
- OK14 OK2026-03-10
Documentation
- Help pages
- 18
- Examples that run
- 46%6 run in a plain check · 7 only when donttest examples are enabled (R CMD check --as-cran)
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Repository
Stars over time
Releases over time
Checks run against github.com/justicego/popcomm on 2026-10-18.
No development-tooling practices detected in the upstream repository.
Dependencies
Code & Tests
Datasets
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- 1.0.0Latest
- 0.1.0.12025-04-25
- RR 4.5.0 released · 2025-04-11
Package metadata
- First published
- 2025-04-25
- Total releases
- 2 / 1 yrs
- License
- MIT + file LICENSE OSI
- Minimum R
- ≥ 4.1.0
- Bundled data
- 1.8 MB / 5 files
- Download size
- 1.8 MB
Cite
Cite this package
Run in R for the authors' preferred citation:
citation("PopComm")This package has no citation file, so citation() returns this entry built from DESCRIPTION.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-21, which the citation names so these numbers can be found later. More on citing and the projects behind them.