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PoPdesign

1.1.0Package record

Posterior Predictive (PoP) Design for Phase I Clinical Trials

0packages depend
2.7Kdownloads / year
–test coverage
13/13flavors OK

Overview

About

The primary goal of phase I clinical trials is to find the maximum tolerated dose (MTD). To reach this objective, we introduce a new design for phase I clinical trials, the posterior predictive (PoP) design. The PoP design is an innovative model-assisted design that is as simply as the conventional algorithmic designs as its decision rules can be pre-tabulated prior to the onset of trial, but is of more flexibility of selecting diverse target toxicity rates and cohort sizes. The PoP design has desirable properties, such as coherence and consistency. Moreover, the PoP design provides better empirical performance than the BOIN and Keyboard design with respect to high average probabilities of choosing the MTD and slightly lower risk of treating patients at subtherapeutic or overly toxic doses.

Install

Health

CRAN checks
13OK
Slowest check: 1.4 min · r-release-macos-x86_64
Status changes
  • OK13 OK2026-09-08
  • ERROR12 OK, 1 ERROR2026-09-07
  • OK13 OK2026-08-05
  • NOTE12 OK, 1 NOTE2026-08-01
  • OK14 OK2026-03-10
Advisories

none known

Documentation

In release 1.1.0
READMEYes · 2 wordsVignettesYes · 1 · dynamicNEWSNoCitation fileYes · cites a publicationWebsitenot declared in DESCRIPTION
Help pages
6
Examples that run
100%4 run in a plain check
Exported functions with examples
100%
Documented parameters
100%
Return-value docs
100%
Help pages citing references
33%
Vignettes (1)

Downloads

2.7K
CRAN downloads in the past year
Rank #19,108 · ~7/day · ~228/mo
Daily download trend is not available in this view yet.
29230 days
68390 days
2.7K1 year
Compare downloads with other packages →
Also on64 r2u5 autocran

Dependencies

Declared dependencies
4 external dependencies (excludes base and recommended)

Installing PoPdesign adds 10 packages (7 with compiled code, 8.2 MB of source tarballs). Heaviest: magick 4.4 MB, Rcpp 1.8 MB, curl 714 KB.

Depends (0)
none
Imports (3)
LinkingTo (0)
none
Suggests (1)
Enhances (0)
none
Reverse dependencies
0direct
0indirect

Nothing depends on this yet.

People & History

People (3)
Author, Maintainer since 1.0.0 (2021)
Author
Releases (6)

Pick two releases to compare their code metrics.

  • R
    R 4.6.0 released · 2026-04-24
  • R
    R 4.5.0 released · 2025-04-11
  • 1.1.0Latest
    record
    2024-06-30 · current release · diff ↗
  • R
    R 4.4.0 released · 2024-04-24
  • 1.0.4
    record
    2023-12-10 · diff ↗
  • R
    R 4.3.0 released · 2023-04-21
  • 1.0.3
    record
    2022-10-02 · diff ↗
  • 1.0.2
    record
    2022-09-29 · diff ↗
  • R
    R 4.2.0 released · 2022-04-22
  • 1.0.1
    record
    2022-02-27 · diff ↗
  • 1.0.0
    record
    2021-12-08
  • R
    R 4.1.0 released · 2021-05-18

Package metadata

First published
2021-12-08
Total releases
6 / 5 yrs
License
GPL-2 OSI
Download size
336 KB

Cite

Cite this package

Run in R for the authors' entry:

citation("PoPdesign")

The package provides a citation file, so citation() returns the authors' own entry.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA

Balamuta, J. J. (2026). R Observatory: Metrics for PoPdesign version 1.1.0 [Data set]. HJJB, LLC. Data release v2026-10-21. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-21, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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