Posterior Predictive (PoP) Design for Phase I Clinical Trials
Overview
The primary goal of phase I clinical trials is to find the maximum tolerated dose (MTD). To reach this objective, we introduce a new design for phase I clinical trials, the posterior predictive (PoP) design. The PoP design is an innovative model-assisted design that is as simply as the conventional algorithmic designs as its decision rules can be pre-tabulated prior to the onset of trial, but is of more flexibility of selecting diverse target toxicity rates and cohort sizes. The PoP design has desirable properties, such as coherence and consistency. Moreover, the PoP design provides better empirical performance than the BOIN and Keyboard design with respect to high average probabilities of choosing the MTD and slightly lower risk of treating patients at subtherapeutic or overly toxic doses.
Install
Health
- OK13 OK2026-09-08
- ERROR12 OK, 1 ERROR2026-09-07
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK14 OK2026-03-10
Documentation
- Help pages
- 6
- Examples that run
- 100%4 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 33%
- PoPdesign-vignette HTML
Downloads
Dependencies
Code & Tests
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- 1.1.0Latest
- RR 4.4.0 released · 2024-04-24
- 1.0.42023-12-10 · diff ↗
- RR 4.3.0 released · 2023-04-21
- 1.0.32022-10-02 · diff ↗
- 1.0.22022-09-29 · diff ↗
- RR 4.2.0 released · 2022-04-22
- 1.0.12022-02-27 · diff ↗
- 1.0.02021-12-08
- RR 4.1.0 released · 2021-05-18
Package metadata
- First published
- 2021-12-08
- Total releases
- 6 / 5 yrs
- License
- GPL-2 OSI
- Download size
- 336 KB
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