Multiplex Network Analysis
Overview
Interactions between different biological entities are crucial for the function of biological systems. In such networks, nodes represent biological elements, such as genes, proteins and microbes, and their interactions can be defined by edges, which can be either binary or weighted. The dysregulation of these networks can be associated with different clinical conditions such as diseases and response to treatments. However, such variations often occur locally and do not concern the whole network. To capture local variations of such networks, we propose multiplex network differential analysis (MNDA). MNDA allows to quantify the variations in the local neighborhood of each node (e.g. gene) between the two given clinical states, and to test for statistical significance of such variation. Yousefi et al. (2023) doi:10.1101/2023.01.22.525058.
Install
Health
- OK13 OK2026-09-08
- ERROR12 OK, 1 ERROR2026-09-07
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-09
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- ERROR12 OK, 1 ERROR2026-06-08
- OK14 OK2026-03-10
Documentation
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- 21
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Dependencies
Installing PLEXI adds 67 packages (38 with compiled code, 56 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, igraph 4.8 MB.
Code & Tests
People & History
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 1.0.0Latest2023-08-09 · current release
- RR 4.3.0 released · 2023-04-21
Package metadata
- First published
- 2023-08-09
- Total releases
- 1 / 3 yrs
- License
- GPL (>= 3) OSI
- Download size
- 17 KB
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