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MedianaDesigner

Power and Sample Size Calculations for Clinical Trials

v0.13 · Aug 27, 2023 · GPL-3
CRAN GitHub Mirror

Description

Efficient simulation-based power and sample size calculations are supported for a broad class of late-stage clinical trials. The following modules are included in the package: Adaptive designs with data-driven sample size or event count re-estimation, Adaptive designs with data-driven treatment selection, Adaptive designs with data-driven population selection, Optimal selection of a futility stopping rule, Event prediction in event-driven trials, Adaptive trials with response-adaptive randomization (experimental module), Traditional trials with multiple objectives (experimental module). Traditional trials with cluster-randomized designs (experimental module).

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CRAN Check Status

14 NOTE
Show all 14 flavors
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r-devel-linux-x86_64-debian-clang NOTE
r-devel-linux-x86_64-debian-gcc NOTE
r-devel-linux-x86_64-fedora-clang NOTE
r-devel-linux-x86_64-fedora-gcc NOTE
r-devel-macos-arm64 NOTE
r-devel-windows-x86_64 NOTE
r-oldrel-macos-arm64 NOTE
r-oldrel-macos-x86_64 NOTE
r-oldrel-windows-x86_64 NOTE
r-patched-linux-x86_64 NOTE
r-release-linux-x86_64 NOTE
r-release-macos-arm64 NOTE
r-release-macos-x86_64 NOTE
r-release-windows-x86_64 NOTE
Check details (21 non-OK)
NOTE r-devel-linux-x86_64-debian-clang

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-linux-x86_64-debian-gcc

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-linux-x86_64-fedora-clang

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-linux-x86_64-fedora-gcc

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-macos-arm64

R code for possible problems

ADPopSel: no visible global function definition for ‘%dorng%’
ADRand: no visible global function definition for ‘%dorng%’
ADSSMod: no visible global function definition for ‘%dorng%’
ADTreatSel: no visible global function definition for ‘%dorng%’
ClustRand: no visible global function definition for ‘%dorng%’
EventPred: no visible global function definition for ‘%dorng%’
FutRuleNCores: no visible global function definition for ‘%dorng%’
MultAdj1NCores: no visible global function definition for ‘%dorng%’
MultAdj2NCores: no visible global function definition for ‘%dorng%’
MultAdj3NCores: no visible global function definition for ‘%dorng%’
Undefined global functions or variables:
  %dorng%
NOTE r-devel-macos-arm64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-windows-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-oldrel-macos-arm64

R code for possible problems

ADPopSel: no visible global function definition for ‘%dorng%’
ADRand: no visible global function definition for ‘%dorng%’
ADSSMod: no visible global function definition for ‘%dorng%’
ADTreatSel: no visible global function definition for ‘%dorng%’
ClustRand: no visible global function definition for ‘%dorng%’
EventPred: no visible global function definition for ‘%dorng%’
FutRuleNCores: no visible global function definition for ‘%dorng%’
MultAdj1NCores: no visible global function definition for ‘%dorng%’
MultAdj2NCores: no visible global function definition for ‘%dorng%’
MultAdj3NCores: no visible global function definition for ‘%dorng%’
Undefined global functions or variables:
  %dorng%
NOTE r-oldrel-macos-arm64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-oldrel-macos-arm64

installed package size

installed size is 19.0Mb
  sub-directories of 1Mb or more:
    libs  18.0Mb
NOTE r-oldrel-macos-x86_64

R code for possible problems

ADPopSel: no visible global function definition for ‘%dorng%’
ADRand: no visible global function definition for ‘%dorng%’
ADSSMod: no visible global function definition for ‘%dorng%’
ADTreatSel: no visible global function definition for ‘%dorng%’
ClustRand: no visible global function definition for ‘%dorng%’
EventPred: no visible global function definition for ‘%dorng%’
FutRuleNCores: no visible global function definition for ‘%dorng%’
MultAdj1NCores: no visible global function definition for ‘%dorng%’
MultAdj2NCores: no visible global function definition for ‘%dorng%’
MultAdj3NCores: no visible global function definition for ‘%dorng%’
Undefined global functions or variables:
  %dorng%
NOTE r-oldrel-macos-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-oldrel-macos-x86_64

installed package size

installed size is 19.2Mb
  sub-directories of 1Mb or more:
    libs  18.2Mb
NOTE r-oldrel-windows-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-patched-linux-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-release-linux-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-release-macos-arm64

R code for possible problems

ADPopSel: no visible global function definition for ‘%dorng%’
ADRand: no visible global function definition for ‘%dorng%’
ADSSMod: no visible global function definition for ‘%dorng%’
ADTreatSel: no visible global function definition for ‘%dorng%’
ClustRand: no visible global function definition for ‘%dorng%’
EventPred: no visible global function definition for ‘%dorng%’
FutRuleNCores: no visible global function definition for ‘%dorng%’
MultAdj1NCores: no visible global function definition for ‘%dorng%’
MultAdj2NCores: no visible global function definition for ‘%dorng%’
MultAdj3NCores: no visible global function definition for ‘%dorng%’
Undefined global functions or variables:
  %dorng%
NOTE r-release-macos-arm64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-release-macos-x86_64

R code for possible problems

ADPopSel: no visible global function definition for ‘%dorng%’
ADRand: no visible global function definition for ‘%dorng%’
ADSSMod: no visible global function definition for ‘%dorng%’
ADTreatSel: no visible global function definition for ‘%dorng%’
ClustRand: no visible global function definition for ‘%dorng%’
EventPred: no visible global function definition for ‘%dorng%’
FutRuleNCores: no visible global function definition for ‘%dorng%’
MultAdj1NCores: no visible global function definition for ‘%dorng%’
MultAdj2NCores: no visible global function definition for ‘%dorng%’
MultAdj3NCores: no visible global function definition for ‘%dorng%’
Undefined global functions or variables:
  %dorng%
NOTE r-release-macos-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-release-windows-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 |     \item \code{direction}{: Character value defining the direction of favorable outcome. Possible values: \code{"Higher"} (a higher value of the endpoint indicates a more favorable outcome) and \code{"Lower"} (a lower value of the endpoint indicates a more favorable outcome).}    
       |                           ^
checkRd: (-1) ADPopSel.Rd:25: Lost braces
    25 |     \item \code{sample_size}{: Integer vector with two elements defining the number of enrolled patients in the two trial arms (control and experimental treatment). Each element must be positive.}
       |                             ^
checkRd: (-1) ADPopSel.Rd:26: Lost braces
    26 |     \item \code{control_mean}{: Numeric value defining the mean of the primary endpoint in
...[truncated]...
out_rate}{: Numeric value defining the patient dropout rate. A uniform patient dropout process is assumed and thus this parameter defines the fraction of patients that will be excluded from the analysis. This value must be between 0 and 1.}
       |                              ^
checkRd: (-1) MultAdj.Rd:65: Lost braces in \itemize; meant \describe ?
checkRd: (-1) MultAdj.Rd:66: Lost braces
    66 |     \item \code{random_seed}{: Integer value defining the random number generator seed. The default value is 49283.}
       |                             ^
checkRd: (-1) MultAdj.Rd:67: Lost braces
    67 |     \item \code{nsims}{: Integer value defining the number of simulation runs.}
       |                       ^
checkRd: (-1) MultAdj.Rd:68: Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^

Check History

NOTE 0 OK · 14 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
NOTE r-devel-linux-x86_64-debian-clang

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-linux-x86_64-debian-gcc

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-linux-x86_64-fedora-clang

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-linux-x86_64-fedora-gcc

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-devel-macos-arm64

R code for possible problems

ADPopSel: no visible global function definition for ‘%dorng%’
ADRand: no visible global function definition for ‘%dorng%’
ADSSMod: no visible global function definition for ‘%dorng%’
ADTreatSel: no visible global function definition for ‘%dorng%’
Clu
...[truncated]...
Adj1NCores: no visible global function definition for ‘%dorng%’
MultAdj2NCores: no visible global function definition for ‘%dorng%’
MultAdj3NCores: no visible global function definition for ‘%dorng%’
Undefined global functions or variables:
  %dorng%
NOTE r-devel-windows-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-patched-linux-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-release-linux-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-release-macos-arm64

R code for possible problems

ADPopSel: no visible global function definition for ‘%dorng%’
ADRand: no visible global function definition for ‘%dorng%’
ADSSMod: no visible global function definition for ‘%dorng%’
ADTreatSel: no visible global function definition for ‘%dorng%’
Clu
...[truncated]...
Adj1NCores: no visible global function definition for ‘%dorng%’
MultAdj2NCores: no visible global function definition for ‘%dorng%’
MultAdj3NCores: no visible global function definition for ‘%dorng%’
Undefined global functions or variables:
  %dorng%
NOTE r-release-macos-x86_64

R code for possible problems

ADPopSel: no visible global function definition for ‘%dorng%’
ADRand: no visible global function definition for ‘%dorng%’
ADSSMod: no visible global function definition for ‘%dorng%’
ADTreatSel: no visible global function definition for ‘%dorng%’
Clu
...[truncated]...
Adj1NCores: no visible global function definition for ‘%dorng%’
MultAdj2NCores: no visible global function definition for ‘%dorng%’
MultAdj3NCores: no visible global function definition for ‘%dorng%’
Undefined global functions or variables:
  %dorng%
NOTE r-release-windows-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^
NOTE r-oldrel-macos-arm64

installed package size

installed size is 19.0Mb
  sub-directories of 1Mb or more:
    libs  18.0Mb
NOTE r-oldrel-macos-x86_64

installed package size

installed size is 19.2Mb
  sub-directories of 1Mb or more:
    libs  18.2Mb
NOTE r-oldrel-windows-x86_64

Rd files

checkRd: (-1) ADPopSel.Rd:17-23: Lost braces
    17 |     \item \code{endpoint_type}{: Character value defining the primary endpoint's type. Possible values:  
       |                               ^
checkRd: (-1) ADPopSel.Rd:24: Lost braces
    24 
...[truncated]...
 Lost braces
    68 |     \item \code{ncores}{: Integer value defining the number of cores for parallel calculations. The number of cores cannot exceed the maximum available number of cores. The default value is 1.} 
       |                        ^

Dependency Network

Dependencies Reverse dependencies Rcpp RcppNumerical officer flextable devEMF mvtnorm shiny shinydashboard shinyMatrix foreach doParallel MASS rootSolve lme4 lmerTest +1 more dependencies MedianaDesigner

Version History

new 0.13 Mar 10, 2026
updated 0.13 ← 0.12 diff Aug 27, 2023
updated 0.12 ← 0.11 diff Jan 11, 2023
updated 0.11 ← 0.10 diff Dec 15, 2022
updated 0.10 ← 0.9 diff Oct 31, 2022
updated 0.9 ← 0.8 diff Oct 27, 2022
updated 0.8 ← 0.7 diff Jun 23, 2022
updated 0.7 ← 0.6 diff Dec 18, 2021
updated 0.6 ← 0.5 diff Oct 31, 2021
updated 0.5 ← 0.4 diff Oct 10, 2021
updated 0.4 ← 0.3 diff Oct 5, 2021
updated 0.3 ← 0.2.3 diff Sep 19, 2021
updated 0.2.3 ← 0.2.2 diff Aug 15, 2021
updated 0.2.2 ← 0.2 diff Jul 27, 2021
new 0.2 Jul 7, 2021