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Machine Learning Imputation, Clustering and Survival Analysis for Longitudinal Proteomic Data

0packages depend
335downloads / year
51.7%test coverage
13/13flavors OK

Overview

About

Imputes missing biomarker measurements in a wide longitudinal serum panel with gradient-boosted decision trees, groups the completed panel by Bayesian consensus clustering, and compares the resulting patient subgroups by Kaplan-Meier, log-rank and Cox analysis. The imputation learner is described in Ke et al. (2017) https://papers.nips.cc/paper/6907-lightgbm-a-highly-efficient-gradient-boosting-decision-tree and the clustering method in Lock and Dunson (2013) doi:10.1093/bioinformatics/btt425. Imputed values are conditional-mean predictions, so the procedure is a machine-learning single imputation; the completions carry no between-imputation variance and must not be pooled by Rubin's rules. Two panels from Gene Expression Omnibus accession 'GSE65622' are included, one for each survival endpoint.

Changes in 0.1.0

First release.

  • miml_rfs() runs the published workflow on RFS_data.
  • miml_mfs() runs it on MFS_data.
  • RFS_data and MFS_data: 80 patients, 288 patient-visits, 507 protein biomarkers, about 10.3 percent missing, from GEO accession GSE65622.

From NEWS.md in the release

Install

Health

CRAN checks
13OK
Slowest check: 1.1 min · r-oldrel-windows-x86_64
Status changes
  • OK13 OKNow
  • OK5 OK2026-10-01
Advisories

none known

Documentation

In release 0.1.0
READMENoVignettesNoNEWSYes · 67% structured · mentions 0.1.0Citation fileNoWebsitenot declared in DESCRIPTION
Help pages
5 (1 internal)includes a package overview page
Examples that run
100%4 run in a plain check
Exported functions with examples
100%
Documented parameters
100%
Return-value docs
100%
Help pages citing references
20%

Downloads

335
CRAN downloads in the past year
Rank #25,293 · ~1/day · ~28/mo
MIML
Daily download trend is not available in this view yet.
33530 days
33590 days
3351 year
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Dependencies

Declared dependencies
4 external dependencies (excludes base and recommended)

Installing MIML adds 4 packages (3 with compiled code, 8.5 MB of source tarballs). Heaviest: data.table 5.7 MB, lightgbm 1.7 MB, jsonlite 1.0 MB.

Depends (1)
R >= 4.1.0
Imports (5)
lightgbmdata.tablesurvivalstatsutils
LinkingTo (0)
none
Suggests (2)
Enhances (0)
none
Reverse dependencies
0direct
0indirect

Nothing depends on this yet.

Datasets

People & History

People (4)
Author, Maintainer since 0.1.0 (2026)
Listed in earlier versions (1)
Gajendra K.
no longer listed · 0.1.0
Releases (1)
  • 0.1.0Latest
    2026-09-30 · current release
  • R
    R 4.6.0 released · 2026-04-24

Package metadata

First published
2026-09-30
Total releases
1 / 1 yrs
License
GPL-3 OSI
Minimum R
≥ 4.1.0
Bundled data
1.6 MB / 2 files
Download size
1.6 MB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("MIML")
Kumar, N., Bhattacharjee, A., Majumdar, T., & Vishwakarma, G. K. (2026). MIML: Machine Learning Imputation, Clustering and Survival Analysis for Longitudinal Proteomic Data (Version 0.1.0) [Computer software]. https://doi.org/10.32614/CRAN.package.MIML

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA

Balamuta, J. J. (2026). R Observatory: Metrics for MIML version 0.1.0 [Data set]. HJJB, LLC. Data release v2026-10-22. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-22, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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