Machine Learning Imputation, Clustering and Survival Analysis for Longitudinal Proteomic Data
Overview
Imputes missing biomarker measurements in a wide longitudinal serum panel with gradient-boosted decision trees, groups the completed panel by Bayesian consensus clustering, and compares the resulting patient subgroups by Kaplan-Meier, log-rank and Cox analysis. The imputation learner is described in Ke et al. (2017) https://papers.nips.cc/paper/6907-lightgbm-a-highly-efficient-gradient-boosting-decision-tree and the clustering method in Lock and Dunson (2013) doi:10.1093/bioinformatics/btt425. Imputed values are conditional-mean predictions, so the procedure is a machine-learning single imputation; the completions carry no between-imputation variance and must not be pooled by Rubin's rules. Two panels from Gene Expression Omnibus accession 'GSE65622' are included, one for each survival endpoint.
First release.
miml_rfs()runs the published workflow onRFS_data.miml_mfs()runs it onMFS_data.RFS_dataandMFS_data: 80 patients, 288 patient-visits, 507 protein biomarkers, about 10.3 percent missing, from GEO accession GSE65622.
From NEWS.md in the release
Install
Health
- OK13 OKNow
- OK5 OK2026-10-01
Documentation
- Help pages
- 5 (1 internal)includes a package overview page
- Examples that run
- 100%4 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 20%
Downloads
Dependencies
Installing MIML adds 4 packages (3 with compiled code, 8.5 MB of source tarballs). Heaviest: data.table 5.7 MB, lightgbm 1.7 MB, jsonlite 1.0 MB.
Code & Tests
Datasets
People & History
- 0.1.0Latest2026-09-30 · current release
- RR 4.6.0 released · 2026-04-24
Package metadata
- First published
- 2026-09-30
- Total releases
- 1 / 1 yrs
- License
- GPL-3 OSI
- Minimum R
- ≥ 4.1.0
- Bundled data
- 1.6 MB / 2 files
- Download size
- 1.6 MB
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