Implementation of LT-FH++
Overview
Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) doi:10.1016/j.ajhg.2022.01.009 as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) https://www.nature.com/articles/s41467-023-41210-z as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.
- Added several functions to assist labelling relatives, summarising per-family relatives, and summary pedigree information visualisation
- get_generations()
- label_relatives()
- get_relations()
- get_family_graphs()
- Relation_per_proband_plot()
- Added vignette on pedigree visualisation and labelling relatives
From NEWS.md in the release
Install
Health
- OK13 OK2026-09-08
- ERROR12 OK, 1 ERROR2026-09-07
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK14 OK2026-04-22
Show 2 earlier changesHide 2 earlier changes
- ERROR13 OK, 1 ERROR2026-04-18
- OK14 OK2026-03-10
Documentation
- Help pages
- 36 (1 internal)includes a package overview page
- Examples that run
- 82%27 run in a plain check · 6 hold no code
- Exported functions with examples
- 97%
- Documented parameters
- 97%
- Return-value docs
- 100%
- Help pages citing references
- 6%
Downloads
Repository
- PRs merged (all time)
- 100%
- Median days to close, 50 most recently updated closed issues
- 8
- Median days to close, 50 most recently updated closed PRs
- 0
Stars over time
Forks over time
Releases over time
Issues over time
PRs over time
8 development-tooling and community-health practices detected across 4 families in the upstream repository
Checks run against github.com/emilmip/ltfhplus on 2026-10-25.
The R CMD check workflow runs on Linux
GitHub Pages site last deployed 2025-11-17 · The repository has a site deploy workflow
pkgdown site last built 2025-11-17
Dependencies
Installing LTFHPlus adds 46 packages (26 with compiled code, 48 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, data.table 5.7 MB.
Code & Tests
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- 2.2.0Latest2025-11-17 · current release · diff ↗ ·
added 7 exports
Relation_per_proband_plot, attach_attributes, familywise_attach_attributes, get_family_graphs, get_generations, get_relations, label_relatives - 2.1.42025-05-26 · diff ↗
- 2.1.3
- RR 4.5.0 released · 2025-04-11
- 2.1.22024-11-22 · diff ↗
- RR 4.4.0 released · 2024-04-24
- 2.1.12024-02-12
- RR 4.3.0 released · 2023-04-21
Package metadata
- First published
- 2024-02-12
- Total releases
- 5 / 2 yrs
- License
- GPL-3 OSI
- Download size
- 84 KB
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