LEANR
1.4.9Finds "Local Subnetworks" Within an Interaction Network which Show Enrichment for Differentially Expressed Genes
Overview
Implements the method described in "Network-based analysis of omics data: The LEAN method" [Gwinner Boulday (2016) DOI:10.1093/bioinformatics/btw676] Given a protein interaction network and a list of p-values describing a measure of interest (as e.g. differential gene expression) this method computes an enrichment p-value for the protein neighborhood of each gene and compares it to a background distribution of randomly drawn p-values. The resulting scores are corrected for multiple testing and significant hits are returned in tabular format.
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People & History
1 release. R releases are shown for context.
- RR 4.4.0 released · 2024-04-24
- archivedRemoved from CRAN2024-04-20issues were not corrected despite reminders
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- RR 3.5.0 released · 2018-04-23
- RR 3.4.0 released · 2017-04-21
- 1.4.92016-11-12
- RR 3.3.0 released · 2016-05-03
Package metadata
- Total releases
- 1
- License
- GPL-3 OSI
- Minimum R
- ≥ 2.14
- Bundled data
- 1.4 MB / 7 files
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