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Keyboard

0.1.3Package record

Bayesian Designs for Early Phase Clinical Trials

0packages depend
2.7Kdownloads / year
–test coverage
11/13flavors OK

Overview

About

We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) doi:10.1158/1078-0432.CCR-17-0220, Li DH, Whitmore JB, Guo W, Ji Y. (2017) doi:10.1158/1078-0432.CCR-16-1125, Liu S, Johnson VE (2016) doi:10.1093/biostatistics/kxv040, Zhou Y, Lee JJ, Yuan Y (2019) doi:10.1002/sim.8475, Pan H, Lin R, Yuan Y (2020) doi:10.1016/j.cct.2020.105972). The 'Keyboard' package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials. For more details about how to use this packge, please refer to Li C, Sun H, Cheng C, Tang L, and Pan H. (2022) "A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs". Manuscript submitted for publication.

Install

Health

CRAN checks
2NOTE11OK
Check messages
NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Xiaomeng",
                      family = "Yuan",
                      role = c("aut", "cre"),
                      email = "xiaomeng.yuan@stjude.org"),
               person(given = "Chen",
                      family = "Li",
                      role = "aut"),
               person(given = "Hongying",
                      family = "Sun",
                      role = "aut"),
               person(given = "Li",
                      family = "Tang",
                      role = "aut"),
               person(given = "Haitao",
                      family = "Pan",
                      role = "aut"))
as necessary.

CRAN check page ↗

Slowest check: 2.0 min · r-oldrel-windows-x86_64
Status changes
  • NOTE11 OK, 2 NOTENow
  • NOTE12 OK, 2 NOTE2026-03-10
Advisories

none known

Documentation

In release 0.1.3
READMENoVignettesNoNEWSNoCitation fileNoWebsitenot declared in DESCRIPTION
Help pages
16
Examples that run
50%8 run in a plain check · 8 only when donttest examples are enabled (R CMD check --as-cran)
Exported functions with examples
100%
Documented parameters
98%
Return-value docs
100%
Help pages citing references
81%

Downloads

2.7K
CRAN downloads in the past year
Rank #17,813 · ~7/day · ~225/mo
Daily download trend is not available in this view yet.
27530 days
71990 days
2.7K1 year
Compare downloads with other packages →
Also on69 r2u5 autocran82 c2d4u

Dependencies

Declared dependencies
3 external dependencies (excludes base and recommended)

Installing Keyboard adds 19 packages (9 with compiled code, 16 MB of source tarballs). Heaviest: ggplot2 6.0 MB, Rcpp 1.8 MB, isoband 1.5 MB.

Depends (3)
R >= 3.4.0Rcppmethods
Imports (2)
LinkingTo (0)
none
Suggests (0)
none
Enhances (0)
none
Reverse dependencies
0direct
0indirect

Nothing depends on this yet.

People & History

People (from the free-text Author field) (5)
· added in 0.1.3
· added in 0.1.3

Maintainer since 0.1.3 (2022), previously Hongying Sun (0.1.0)

Releases (2)

Pick two releases to compare their code metrics.

  • R
    R 4.6.0 released · 2026-04-24
  • R
    R 4.5.0 released · 2025-04-11
  • R
    R 4.4.0 released · 2024-04-24
  • R
    R 4.3.0 released · 2023-04-21
  • unarchivedReturned to CRAN
    2022-08-11
  • 0.1.3Latest
    record
    2022-08-11 · current release · diff ↗ ·
    removed 2 exports
    plot.kb, summary.kb
    added 2 exports
    plot_kb, summary_kb
  • archivedRemoved from CRAN
    2022-05-24
    check problems were not corrected in time
  • R
    R 4.2.0 released · 2022-04-22
  • R
    R 4.1.0 released · 2021-05-18
  • 0.1.0
    record
    2020-07-07
  • R
    R 4.0.0 released · 2020-04-24

Package metadata

First published
2020-07-07
Total releases
2 / 6 yrs
License
GPL-2 OSI
Minimum R
≥ 3.4.0
Download size
105 KB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("Keyboard")

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA

Balamuta, J. J. (2026). R Observatory: Metrics for Keyboard version 0.1.3 [Data set]. HJJB, LLC. Data release v2026-10-21. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-21, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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