Bayesian Designs for Early Phase Clinical Trials
Overview
We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) doi:10.1158/1078-0432.CCR-17-0220, Li DH, Whitmore JB, Guo W, Ji Y. (2017) doi:10.1158/1078-0432.CCR-16-1125, Liu S, Johnson VE (2016) doi:10.1093/biostatistics/kxv040, Zhou Y, Lee JJ, Yuan Y (2019) doi:10.1002/sim.8475, Pan H, Lin R, Yuan Y (2020) doi:10.1016/j.cct.2020.105972). The 'Keyboard' package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials. For more details about how to use this packge, please refer to Li C, Sun H, Cheng C, Tang L, and Pan H. (2022) "A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs". Manuscript submitted for publication.
Install
Health
NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
email = "xiaomeng.yuan@stjude.org"),
person(given = "Chen",
family = "Li",
role = "aut"),
person(given = "Hongying",
family = "Sun",
role = "aut"),
person(given = "Li",
family = "Tang",
role = "aut"),
person(given = "Haitao",
family = "Pan",
role = "aut"))
as necessary.- NOTE11 OK, 2 NOTENow
- NOTE12 OK, 2 NOTE2026-03-10
Documentation
- Help pages
- 16
- Examples that run
- 50%8 run in a plain check · 8 only when donttest examples are enabled (R CMD check --as-cran)
- Exported functions with examples
- 100%
- Documented parameters
- 98%
- Return-value docs
- 100%
- Help pages citing references
- 81%
Downloads
Dependencies
Code & Tests
People & History
Maintainer since 0.1.3 (2022), previously Hongying Sun (0.1.0)
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- unarchivedReturned to CRAN2022-08-11
- 0.1.3Latest2022-08-11 · current release · diff ↗ ·
removed 2 exports
plot.kb, summary.kbadded 2 exports
plot_kb, summary_kb - archivedRemoved from CRAN2022-05-24check problems were not corrected in time
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- 0.1.02020-07-07
- RR 4.0.0 released · 2020-04-24
Package metadata
- First published
- 2020-07-07
- Total releases
- 2 / 6 yrs
- License
- GPL-2 OSI
- Minimum R
- ≥ 3.4.0
- Download size
- 105 KB
Cite
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