Skip to content

Genome-Wide Robust Analysis for Biobank Data (GRAB)

0packages depend
4.4Kdownloads / year
–test coverage
13/13flavors OK

Overview

About

Provides a comprehensive suite of genome-wide association study (GWAS) methods specifically designed for biobank-scale data, including but not limited to, robust approaches for time-to-event traits (Li et al., 2025 doi:10.1038/s43588-025-00864-z) and ordinal categorical traits (Bi et al., 2021 doi:10.1016/j.ajhg.2021.03.019). The package also offers general frameworks for GWAS of any trait type (Bi et al., 2020 doi:10.1016/j.ajhg.2020.06.003), while accounting for sample relatedness (Xu et al., 2025 doi:10.1038/s41467-025-56669-1) or population structure (Ma et al., 2025 doi:10.1186/s13059-025-03827-9). By accurately approximating score statistic distributions using saddlepoint approximation (SPA), these methods can effectively control type I error rates for rare variants and in the presence of unbalanced phenotype distributions. Additionally, the package includes functions for simulating genotype and phenotype data to support research and method development.

Install

Health

CRAN checks
13OK
Slowest check: 7.1 min · r-oldrel-windows-x86_64
Status changes
  • OK13 OK2026-08-05
  • NOTE12 OK, 1 NOTE2026-08-01
  • OK13 OK2026-06-09
  • ERROR12 OK, 1 ERROR2026-06-08
  • OK13 OK2026-05-02
Show 3 earlier changesHide 3 earlier changes
  • NOTE12 OK, 2 NOTE2026-04-22
  • ERROR11 OK, 2 NOTE, 1 ERROR2026-04-18
  • NOTE12 OK, 2 NOTE2026-03-10
Advisories

none known

Documentation

In release 0.2.5
READMEYes · 135 wordsVignettesNoNEWSNoCitation fileNoWebsitenot declared in DESCRIPTION
Help pages
28 (5 internal)
Examples that run
93%13 run in a plain check · 1 hold no code
Exported functions with examples
50%
Documented parameters
88%
Return-value docs
100%
Help pages citing references
25%

Downloads

4.4K
CRAN downloads in the past year
Rank #8,240 · ~12/day · ~366/mo
Daily download trend is not available in this view yet.
39330 days
1.1K90 days
4.4K1 year
Compare downloads with other packages →
Also on405 r2u2.9K conda_forge

Dependencies

Declared dependencies
18 external dependencies (excludes base and recommended)

Installing GRAB adds 41 packages (27 with compiled code, 51 MB of source tarballs). Heaviest: BH 14 MB, data.table 5.7 MB, igraph 4.8 MB.

Depends (1)
R >= 3.5.0
Enhances (0)
none
Reverse dependencies
0direct
0indirect

Nothing depends on this yet.

Datasets

People & History

People (6)
Maintainer since 0.2.1 (2025)
Author
Releases (5)

Pick two releases to compare their code metrics.

  • 0.2.5Latest
    record
    2026-07-03 · current release · diff ↗
  • R
    R 4.6.0 released · 2026-04-24
  • 0.2.4
    record
    2025-12-05 · diff ↗ ·
    removed 8 exports
    checkIfSampleIDsExist, getDenseGRM, getSampleIDsFromBGEN, getVersionFromBGEN, handleFormula, makeGroup, setDenseGRM, TestforBatchEffect
    added 1 export
    getPairwiseIBD
  • 0.2.3
    record
    2025-08-20 · diff ↗
  • 0.2.2
    record
    2025-07-29 · diff ↗
  • 0.2.1
    record
    2025-07-25
  • R
    R 4.5.0 released · 2025-04-11

Package metadata

First published
2025-07-25
Total releases
5 / 1 yrs
License
GPL (>= 2) OSI
Minimum R
≥ 3.5.0
Download size
1.7 MB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("GRAB")
Miao, W., Bi, W., Dey, R., Lee, S., Zhao, Z., & Zhou, W. (2026). GRAB: Genome-Wide Robust Analysis for Biobank Data (GRAB) (Version 0.2.5) [Computer software]. https://doi.org/10.32614/CRAN.package.GRAB

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA

Balamuta, J. J. (2026). R Observatory: Metrics for GRAB version 0.2.5 [Data set]. HJJB, LLC. Data release v2026-10-26. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-26, which the citation names so these numbers can be found later. More on citing and the projects behind them.

Report a problem with this page →

Privacy choices

These apply to this browser and are stored on this device only. Nothing about your choice is sent to us.

Read the privacy policy