ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis
Overview
The package can identify the dysregulated canonical pathways by investigating the changes of biological relationships of pathways in the context of gene expression data. (1) The ESEA package constructs a background set of edges by extracting pathway structure (e.g. interaction, regulation, modification, and binding etc.) from the seven public databases (KEGG; Reactome; Biocarta; NCI; SPIKE; HumanCyc; Panther) and the edge sets of pathways for each of the above databases. (2) The ESEA package can can quantify the change of correlation between genes for each edge based on gene expression data with cases and controls. (3) The ESEA package uses the weighted Kolmogorov-Smirnov statistic to calculate an edge enrichment score (EES), which reflects the degree to which a given pathway is associated the specific phenotype. (4) The ESEA package can provide the visualization of the results.
Install
Health
CRAN check results are not tracked yet.
Documentation
- Help pages
- 14 (1 internal)
- Examples that run
- 0%9 never run
- Exported functions with examples
- 100%
- Documented parameters
- not tracked
- Return-value docs
- not tracked
- Help pages citing references
- 14%
Downloads
Dependencies
Code & Tests
Datasets
People & History
Maintainer since 1.0 (2015)
- RR 4.3.0 released · 2023-04-21
- archivedRemoved from CRAN2022-06-20check problems were not corrected despite reminders
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- RR 3.5.0 released · 2018-04-23
- RR 3.4.0 released · 2017-04-21
- RR 3.3.0 released · 2016-05-03
- RR 3.2.0 released · 2015-04-16
- 1.02015-01-22
- RR 3.1.0 released · 2014-04-10
Package metadata
- First published
- 2015-01-22
- Total releases
- 1 / 11 yrs
- License
- GPL (>= 2) OSI
- Minimum R
- ≥ 2.10
- Bundled data
- 1.8 MB / 2 files
Cite
Cite this package
Run in R for the authors' preferred citation:
citation("ESEA")This package has no citation file, so citation() returns this entry built from DESCRIPTION.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-26, which the citation names so these numbers can be found later. More on citing and the projects behind them.