Derive Polygenic Risk Score Based on Emprical Bayes Theory
Overview
EB-PRS is a novel method that leverages information for effect sizes across all the markers to improve the prediction accuracy. No parameter tuning is needed in the method, and no external information is needed. This R-package provides the calculation of polygenic risk scores from the given training summary statistics and testing data. We can use EB-PRS to extract main information, estimate Empirical Bayes parameters, derive polygenic risk scores for each individual in testing data, and evaluate the PRS according to AUC and predictive r2. See Song et al. (2020) doi:10.1371/journal.pcbi.1007565 for a detailed presentation of the method.
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CRAN check results are not tracked yet.
- NOTE12 OK, 2 NOTE2026-03-10
Documentation
- Help pages
- 5
- Examples that run
- 100%2 run in a plain check
- Exported functions with examples
- 25%
- Documented parameters
- 100%
- Return-value docs
- 25%
- Help pages citing references
- 100%
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- archivedRemoved from CRAN2026-05-14email to the maintainer is undeliverable
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- 2.1.0
- 2.0.42020-07-10 · diff ↗
- RR 4.0.0 released · 2020-04-24
- 2.0.32020-02-12 · diff ↗
- 2.0.12020-01-16 · diff ↗ ·
removed 4 exports
extractInfo, findPara, generateScore, getEffectSizeadded 1 export
EBPRS - 1.2.22019-11-07 · diff ↗
- 1.2.12019-10-12 · diff ↗
- 1.2.02019-10-10 · diff ↗
- 1.1.52019-08-07 · diff ↗
Package metadata
- First published
- 2018-11-03
- Total releases
- 10 / 8 yrs
- License
- GPL-3 OSI
- Minimum R
- ≥ 3.5.0
- Bundled data
- 2.9 KB / 1 file
- Download size
- 13 KB
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