R Observatory: Metrics for DTEBOP2 version 1.0.3

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

DTEBOP2

1.0.3Package record

Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes

0packages depend

5.7Kdownloads / year

–test coverage

13/13flavors OK

Overview

About

Maintained by Zhongheng CaiCRAN page ↗

Implements a Bayesian Optimal Phase II design (DTE-BOP2) for trials with delayed treatment effects, particularly relevant to immunotherapy studies where treatment benefits may emerge after a delay. The method builds upon the BOP2 framework and incorporates uncertainty in the delay timepoint through a truncated gamma prior, informed by expert knowledge or default settings. Supports two-arm trial designs with functionality for sample size determination, interim and final analyses, and comprehensive simulation under various delay and design scenarios. Ensures rigorous type I and II error control while improving trial efficiency and power when the delay effect is present. A manuscript describing the methodology is under development and will be formally referenced upon publication.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("DTEBOP2", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-dtebop2

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled. We list this channel from recorded r2u download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-DTEBOP2

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-DTEBOP2

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed). We list this channel from recorded autoCRAN download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

Health

CRAN checks

13OK

CRAN check page ↗

Slowest check: 10.8 min · r-oldrel-windows-x86_64

Status changes

OK13 OK2026-08-05
NOTE12 OK, 1 NOTE2026-08-01
OK13 OK2026-06-09
ERROR12 OK, 1 ERROR2026-06-08
OK14 OK2026-03-10

Advisories

none known

How this is measured·How advisories are found

Documentation

In release 1.0.3

READMENoVignettesYes · 1 · dynamicNEWSNoCitation fileNoWebsitenot declared in DESCRIPTION

Help pages: 12 (1 internal)
Examples that run: 82%9 run in a plain check · 2 only when donttest examples are enabled (R CMD check --as-cran)
Exported functions with examples: 100%
Documented parameters: 99%
Return-value docs: 100%
Help pages citing references: 0%

Vignettes (1)

DTEBOP2 HTML

How these are measured

Downloads

5.7K

CRAN downloads in the past year

Rank #10,778 · ~16/day · ~472/mo

Releases R versions

Daily download trend is not available in this view yet.

33330 days

97590 days

5.7K1 year

Compare downloads with other packages →

Also on66 r2u6 autocran

How downloads are counted

Dependencies

Declared dependencies

10 external dependencies (excludes base and recommended)

Installing DTEBOP2 adds 6 packages (1 with compiled code, 3.9 MB of source tarballs). Heaviest: invgamma 2.5 MB, evd 898 KB, iterators 293 KB.

Depends (1)

R >= 3.5.0

Imports (5)

truncdist doParallel foreachparallelinvgamma

LinkingTo (0)

none

Suggests (7)

knitr rmarkdown survRM2adapt ggplot2 reconstructKMsurvivalsurvminer

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

How these are counted

Code & Tests

Datasets

People & History

People (2)

Zhongheng Cai

Author, Maintainer since 1.0.3 (2025)

Haitao Pan

Author

Releases (1)

R
R 4.6.0 released · 2026-04-24
1.0.3Latest
record
2025-05-09 · current release
R
R 4.5.0 released · 2025-04-11

Package metadata

First published: 2025-05-09
Total releases: 1 / 1 yrs
License: GPL-3 OSI
Minimum R: ≥ 3.5.0
Bundled data: 1.6 KB / 2 files
Download size: 217 KB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("DTEBOP2")

Format

Cai, Z., & Pan, H. (2025). DTEBOP2: Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes (Version 1.0.3) [Computer software]. https://doi.org/10.32614/CRAN.package.DTEBOP2

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for DTEBOP2 version 1.0.3 [Data set]. HJJB, LLC. Data release v2026-10-24. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-24, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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