Differentially Expressed Heterogeneous Overdispersion Gene Test for Count Data
Overview
Implements a generalized linear model approach for detecting differentially expressed genes across treatment groups in count data. The package supports both quasi-Poisson and negative binomial models to handle over-dispersion, ensuring robust identification of differential expression. It allows for the inclusion of treatment effects and gene-wise covariates, as well as normalization factors for accurate scaling across samples. Additionally, it incorporates statistical significance testing with options for p-value adjustment and log2 fold range thresholds, making it suitable for RNA-seq analysis as described in by Xu et al., (2024) doi:10.1371/journal.pone.0300565.
- Initial submission to Bioconductor.
- Implemented functions for quasi-Poisson and negative binomial models.
- Added support for covariates, normalization factors, and p-value adjustment.
From NEWS.md in the release
Install
Health
- OK13 OK2026-10-26
- ERROR12 OK, 1 ERROR2026-10-20
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-07-18
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- ERROR12 OK, 1 ERROR2026-07-14
- OK13 OK2026-05-09
- ERROR12 OK, 1 ERROR2026-05-06
- OK14 OK2026-03-10
Documentation
- Help pages
- 1
- Examples that run
- 100%1 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Repository
1 development-tooling and community-health practice detected across 1 family in the upstream repository
Checks run against github.com/ahshen26/dehogt on 2026-10-25.
Dependencies
Installing DEHOGT adds 3 packages (0 with compiled code, 541 KB of source tarballs). Heaviest: iterators 293 KB, doParallel 160 KB, foreach 88 KB.
Code & Tests
People & History
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- 0.99.0Latest2024-09-13 · current release
- RR 4.4.0 released · 2024-04-24
Package metadata
- First published
- 2024-09-13
- Total releases
- 1 / 2 yrs
- License
- GPL-3 OSI
- Minimum R
- ≥ 3.5.0
- Download size
- 243 KB
Cite
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