Discovery of Candidate Disease Genes Using Trans-Regulatory Effects
Overview
Implements the DANDELION method for prioritizing candidate disease-related proximal genes by integrating trans-regulatory association p-values and gene-level trait association p-values. The statistical testing framework builds on the divide-aggregate composite-null test described by Liu et al. (2022) doi:10.1080/01621459.2021.1914634. The biological application and SNP/gene-based prioritization workflow are motivated by Salamone et al. (under review), "Leveraging trans-gene regulation prioritizes central genes and pathways in asthma". The package provides functions for identifying distal-proximal gene pairs, organizing significant pairs into genomic loci, and visualizing resulting gene networks.
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Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-07-28
- NOTE12 OK, 1 NOTE2026-07-27
- OK6 OK2026-05-05
Documentation
- Help pages
- 7 (1 internal)
- Examples that run
- 100%1 run in a plain check
- Exported functions with examples
- 25%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
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Dependencies
Code & Tests
People & History
- 0.1.0Latest2026-05-04 · current release
- RR 4.6.0 released · 2026-04-24
Package metadata
- First published
- 2026-05-04
- Total releases
- 1 / 1 yrs
- License
- GPL-3 OSI
- Additional repositories
- bioconductor.org
- Download size
- 11 KB
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