CIEE

Estimating and Testing Direct Effects in Directed Acyclic Graphs using Estimating Equations

v0.1.1 · Mar 19, 2018 · GPL-2

Description

In many studies across different disciplines, detailed measures of the variables of interest are available. If assumptions can be made regarding the direction of effects between the assessed variables, this has to be considered in the analysis. The functions in this package implement the novel approach CIEE (causal inference using estimating equations; Konigorski et al., 2018, <DOI:10.1002/gepi.22107>) for estimating and testing the direct effect of an exposure variable on a primary outcome, while adjusting for indirect effects of the exposure on the primary outcome through a secondary intermediate outcome and potential factors influencing the secondary outcome. The underlying directed acyclic graph (DAG) of this considered model is described in the vignette. CIEE can be applied to studies in many different fields, and it is implemented here for the analysis of a continuous primary outcome and a time-to-event primary outcome subject to censoring. CIEE uses estimating equations to obtain estimates of the direct effect and robust sandwich standard error estimates. Then, a large-sample Wald-type test statistic is computed for testing the absence of the direct effect. Additionally, standard multiple regression, regression of residuals, and the structural equation modeling approach are implemented for comparison.

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r-devel-linux-x86_64-debian-clang	NOTE	57s
r-devel-linux-x86_64-debian-gcc	NOTE	41.4s
r-devel-linux-x86_64-fedora-clang	OK	89.7s
r-devel-linux-x86_64-fedora-gcc	OK	117.5s
r-devel-windows-x86_64	OK	79s
r-oldrel-macos-arm64	OK
r-oldrel-macos-x86_64	OK	69s
r-oldrel-windows-x86_64	OK	98s
r-patched-linux-x86_64	OK	54.8s
r-release-linux-x86_64	OK
r-release-macos-arm64	OK	21s
r-release-macos-x86_64	OK	74s
r-release-windows-x86_64	OK	80s

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CRAN incoming feasibility

Maintainer: ‘Stefan Konigorski <stefan.konigorski@gmail.com>’

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CRAN incoming feasibility

Maintainer: ‘Stefan Konigorski <stefan.konigorski@gmail.com>’

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NOTE 10 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Apr 25, 2026

NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Stefan Konigorski <stefan.konigorski@gmail.com>’

Package CITATION file contains call(s) to old-style personList() or
as.personList().  Please use c() on person objects instead.
Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Stefan Konigorski <stefan.konigorski@gmail.com>’

Package CITATION file contains call(s) to old-style personList() or
as.personList().  Please use c() on person objects instead.
Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

ERROR 9 OK · 4 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Mar 30, 2026

NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Stefan Konigorski <stefan.konigorski@gmail.com>’

Package CITATION file contains call(s) to old-style personList() or
as.personList().  Please use c() on person objects instead.
Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Stefan Konigorski <stefan.konigorski@gmail.com>’

Package CITATION file contains call(s) to old-style personList() or
as.personList().  Please use c() on person objects instead.
Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

NOTE r-oldrel-macos-arm64

LazyData

'LazyData' is specified without a 'data' directory

NOTE r-oldrel-macos-x86_64

LazyData

'LazyData' is specified without a 'data' directory

ERROR r-oldrel-windows-x86_64

LazyData

'LazyData' is specified without a 'data' directory

NOTE 9 OK · 5 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026

NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Stefan Konigorski <stefan.konigorski@gmail.com>’

Package CITATION file contains call(s) to old-style personList() or
as.personList().  Please use c() on person objects instead.
Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Stefan Konigorski <stefan.konigorski@gmail.com>’

Package CITATION file contains call(s) to old-style personList() or
as.personList().  Please use c() on person objects instead.
Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

NOTE r-oldrel-macos-arm64

LazyData

'LazyData' is specified without a 'data' directory

NOTE r-oldrel-macos-x86_64

LazyData

'LazyData' is specified without a 'data' directory

NOTE r-oldrel-windows-x86_64

LazyData

'LazyData' is specified without a 'data' directory

Dependency Network

Version History

3 tracked

new 0.1.1 Mar 10, 2026

updated 0.1.1 ← 0.1.0 diff Mar 18, 2018

new 0.1.0 Nov 15, 2017