Rank-Based Compositional Analysis using Log-Linear Models for Microbiome Data with Zero Cells
Overview
Provides rank-based compositional differential abundance analysis for microbiome count data with zero cells using the compositional accelerated failure time model of Satten, Li and Zhao (2025) "CAFT: A Compositional Log-Linear Model for Microbiome Data with Zero Cells" doi:10.1101/2025.11.26.690468. Zero counts are treated as censored observations below sample-specific detection limits, avoiding the use of pseudocounts. The package implements estimation and hypothesis testing procedures for assessing associations between microbial taxa and covariates while accounting for the compositional structure of sequencing count data. It supports taxon-level differential abundance analysis, estimation of regression effects under censoring induced by detection limits, and inference based on rank-based methods that remain applicable in the presence of excess zeros. Functions are provided for model fitting, significance testing, extraction of effect estimates, and summarization of results across taxa. The package also provides optional bootstrap calibration of taxon-level p-values for sensitivity analysis in small-taxon settings.
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK7 OK2026-06-26
Documentation
- Help pages
- 9
- Examples that run
- 100%7 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 11%
Downloads
Repository
- PRs merged (all time)
- not measured
- Median days to close, 50 most recently updated closed issues
- 26
- Median days to close, 50 most recently updated closed PRs
- not measured
Releases over time
Issues over time
1 development-tooling and community-health practice detected across 1 family in the upstream repository
Checks run against github.com/mli171/caft on 2026-10-21.
Dependencies
Code & Tests
Datasets
People & History
- 0.1.0Latest2026-06-25 · current release
- RR 4.6.0 released · 2026-04-24
Package metadata
- First published
- 2026-06-25
- Total releases
- 1 / 1 yrs
- License
- LGPL (>= 2) OSI
- Minimum R
- ≥ 4.3.0
- Bundled data
- 316 KB / 2 files
- Download size
- 411 KB
Cite
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Run in R for the authors' preferred citation:
citation("CAFT")This package has no citation file, so citation() returns this entry built from DESCRIPTION.
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