From Biological Sequences and Simulations to Correlation Analysis
Overview
Utilities for computation and analysis of correlation/covariation in multiple sequence alignments and in side chain motions during molecular dynamics simulations. Features include the computation of correlation/covariation scores using a variety of scoring functions between either sequence positions in alignments or side chain dihedral angles in molecular dynamics simulations and utilities to analyze the correlation/covariation matrix through a variety of tools including network representation and principal components analysis. In addition, several utility functions are based on the R graphical environment to provide friendly tools for help in data interpretation. Examples of sequence covariation analysis are provided in: (1) Pele J, Moreau M, Abdi H, Rodien P, Castel H, Chabbert M (2014) doi:10.1002/prot.24570 and (2) Taddese B, Deniaud M, Garnier A, Tiss A, Guissouma H, Abdi H, Henrion D, Chabbert M (2018) doi:10.1371/journal.pcbi.1006209. An example of side chain correlated motion analysis is provided in: Taddese B, Garnier A, Abdi H, Henrion D, Chabbert M (2020) doi:10.1038/s41598-020-72766-1. This work was supported by the French National Research Agency (Grant number: ANR-11-BSV2-026) and by GENCI (Grant number: 100567).
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK14 OK2026-03-10
Documentation
- Help pages
- 31includes a package overview page
- Examples that run
- 100%31 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 92%
- Return-value docs
- 100%
- Help pages citing references
- 52%
Downloads
Dependencies
Code & Tests
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- unarchivedReturned to CRAN2024-11-14
- 2.2.2Latest
- RR 4.4.0 released · 2024-04-24
- archivedRemoved from CRAN2024-04-20issues were not corrected despite reminders
- RR 4.3.0 released · 2023-04-21
- 2.2.12022-07-08 · diff ↗
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- 2.22020-10-02 · diff ↗
- RR 4.0.0 released · 2020-04-24
- 2.12020-01-30 · diff ↗
- 2.02019-10-31 · diff ↗ ·
removed 23 exports
ang_evo_graph, angle_conversion, corr_contact, create_boxplot, create_corrfile, create_entropyfile, create_network, create_pcafile, create_screeplot, cyto_entropy, cyto_zscore, delta_weighting, dynamic_struct, entropy_graph, gauss_weighting, rotamer_circular, rotamer_entropy, rotamer_mip, rotamer_omes, shuffle_all, shuffle_positions, sigmoid_weighting, write_pdbadded 19 exports
angles.plot, angle2rotamer, top_pairs_analysis, scores.boxplot, write.scores, write.entropy, network.plot, write.pca, pca_screeplot, delta_filter, dynamic_structure, scores_entropy.plot, mi, dynamic_circular, dynamic_mi, dynamic_mip, dynamic_omes, dynamic_entropy, write.pca.pdb - RR 3.6.0 released · 2019-04-26
- RR 3.5.0 released · 2018-04-23
Package metadata
- First published
- 2017-08-24
- Total releases
- 7 / 9 yrs
- License
- GPL (>= 2) OSI
- Minimum R
- ≥ 3.5
- Download size
- 863 KB
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