R Observatory: Metrics for BIGL version 1.9.3

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

BIGL

1.9.3Package record

Biochemically Intuitive Generalized Loewe Model

0packages depend

5.5Kdownloads / year

66.2%test coverage

13/13flavors OK

Overview

About

Maintained by Kathy MutambanengweCRAN page ↗GitHub ↗Issues ↗

Response surface methods for drug synergy analysis. Available methods include generalized and classical Loewe formulations as well as Highest Single Agent methodology. Response surfaces can be plotted in an interactive 3-D plot and formal statistical tests for presence of synergistic effects are available. Implemented methods and tests are described in the article "BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism" by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas, Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017) doi:10.1038/s41598-017-18068-5.

Changes in 1.9.3

allow specification of text size and own colours in plotConfInt
fix bug isolating points in 3D plot

From NEWS.md in the release

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("BIGL", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("openanalytics/BIGL")

Development version from openanalytics/BIGL. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-bigl

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled. We list this channel from recorded r2u download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-BIGL

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-BIGL

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed). We list this channel from recorded autoCRAN download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

Health

CRAN checks

13OK

CRAN check page ↗

Slowest check: 5.7 min · r-oldrel-windows-x86_64

Status changes

OK13 OK2026-08-05
NOTE12 OK, 1 NOTE2026-08-01
OK13 OK2026-06-09
ERROR12 OK, 1 ERROR2026-06-08
OK14 OK2026-03-10

Advisories

none known

How this is measured·How advisories are found

Documentation

In release 1.9.3

README· In the repository, left out of the releaseVignettesYes · 2 · dynamicNEWSYes · 100% structured · mentions 1.9.3Citation fileNoWebsitenot declared in DESCRIPTION

Help pages: 68
Examples that run: 62%8 run in a plain check · 1 only when donttest examples are enabled (R CMD check --as-cran) · 4 never run
Exported functions with examples: 81%
Documented parameters: 92%
Return-value docs: 75%
Help pages citing references: 0%

Vignettes (2)

How these are measured

Downloads

5.5K

CRAN downloads in the past year

Rank #5,635 · ~15/day · ~457/mo

Releases R versions

Daily download trend is not available in this view yet.

67130 days

1.5K90 days

5.5K1 year

Compare downloads with other packages →

Also on113 r2u23 autocran

How downloads are counted

Repository

openanalytics/bigl ↗Organization: openanalytics

8Stars

7Forks

2Open issues

0Open PRs

0Releases

153Commits

6Commit identities

License file reads as GPL-3.0 · 153 commits · Last activity 2023-06-13 · 0% stars, 30d · The default branch showed an older version (1.8.0) than CRAN on 2026-10-21

Responsiveness

How these are sampled

PRs merged (all time): 50%
Median days to close, 50 most recently updated closed issues: 286
Median days to close, 50 most recently updated closed PRs: 71

Stars over time

2021-12-21 · 72026-07-07 · 8

How these are measured

PracticesBeta

Checks run against github.com/openanalytics/bigl on 2026-10-21.

No development-tooling practices detected in the upstream repository.

How this is detected·Detection ruleset v4 (2026-10-20)

Dependencies

Declared dependencies

17 external dependencies (excludes base and recommended)

Installing BIGL adds 73 packages (38 with compiled code, 65 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, data.table 5.7 MB.

Depends (1)

R >= 3.5

Imports (15)

ggplot2MASSmethodsminpack.lm numDerivparallelprogress plotly robustbase scales nleqslv data.table lifecycle htmlwidgets magrittr

LinkingTo (0)

none

Suggests (5)

knitr rmarkdown testthat shiny DT

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

How these are counted

Code & Tests

Datasets

People & History

People (8)

Kathy Mutambanengwe

Author, Maintainer since 1.9.0 (2023) · added in 1.9.0

Rytis Bagdziunas

Author

Stijn Hawinkel

Author · added in 1.6.0

Maxim Nazarov

Author

Javier Franco Pérez

Author · added in 1.7.0

Olivier Thas

Author

Annelies Tourny

Author

Heather Turner

Author

Previously maintained by Maxim Nazarov (1.1.0 to 1.8.0) and Rytis Bagdziunas (1.0.1).

Listed in earlier versions (1)

Pérez

no longer listed · 1.9.3

Releases (27)

Pick two releases to compare their code metrics.

R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
1.9.3Latest
record
2024-08-01 · current release · diff ↗
1.9.2
record
2024-06-26 · diff ↗
1.9.1
record
2024-05-22 · diff ↗
R
R 4.4.0 released · 2024-04-24
1.9.0
record
2023-12-21 · diff ↗
1.8.0
record
2023-06-13 · diff ↗ ·
added 1 export
synergy_plot_bycomp
R
R 4.3.0 released · 2023-04-21
1.7.0
record
2023-03-08 · diff ↗
1.6.7
record
2023-01-26 · diff ↗
1.6.6
record
2022-05-05 · diff ↗
R
R 4.2.0 released · 2022-04-22
1.6.5
record
2021-10-27 · diff ↗
1.6.4
record
2021-09-02 · diff ↗
1.6.3
record
2021-06-30 · diff ↗

Show 23 earlier eventsHide 23 earlier events

R
R 4.1.0 released · 2021-05-18
1.6.2
record
2021-03-10 · diff ↗
unarchivedReturned to CRAN
2021-01-24
1.6.1
record
2021-01-24 · diff ↗
archivedRemoved from CRAN
2021-01-12
check problems were not corrected in time
1.6.0
record
2020-12-16 · diff ↗ ·
removed 3 exports
CPBootstrap, maxR, meanR

added 2 exports
plotConfInt, plotMeanVarFit
1.5.3
record
2020-09-10 · diff ↗
1.5.2
record
2020-07-24 · diff ↗
1.5.1
record
2020-07-07 · diff ↗
R
R 4.0.0 released · 2020-04-24
1.4.3
record
2020-02-20 · diff ↗
1.4.2
record
2020-01-20 · diff ↗
1.4.1
record
2019-06-21 · diff ↗
R
R 3.6.0 released · 2019-04-26
1.3.0
record
2019-02-28 · diff ↗
1.2.3
record
2018-11-21 · diff ↗
1.2.2
record
2018-09-10 · diff ↗
1.2.0
record
2018-06-13 · diff ↗
R
R 3.5.0 released · 2018-04-23
1.1.1
record
2018-01-03 · diff ↗
1.1.0
record
2017-09-25 · diff ↗ ·
added 1 export
isobologram
1.0.1
record
2017-06-30
R
R 3.4.0 released · 2017-04-21

Package metadata

First published: 2017-06-30
Total releases: 27 / 9 yrs
License: GPL-3 OSI
Minimum R: ≥ 3.5
Bundled data: 40 KB / 2 files
Download size: 1.4 MB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("BIGL")

Format

Mutambanengwe, K., Bagdziunas, R., Hawinkel, S., Nazarov, M., Pérez, J. F., Thas, O., Tourny, A., & Turner, H. (2024). BIGL: Biochemically Intuitive Generalized Loewe Model (Version 1.9.3) [Computer software]. https://doi.org/10.32614/CRAN.package.BIGL

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for BIGL version 1.9.3 [Data set]. HJJB, LLC. Data release v2026-10-23. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-23, which the citation names so these numbers can be found later. More on citing and the projects behind them.

Report a problem with this page →