Beta-Binomial Models for Vaccine-Specific Memory B Cell Frequency and Power Calculations
Overview
Provides tools to model overdispersed vaccine-specific memory B cell frequencies using Beta-Binomial generalized linear models, specifically designed for analyzing vaccine-induced cellular immune responses. Includes method-of-moments dispersion estimation, likelihood ratio testing across experimental arms, and Monte Carlo simulation frameworks to calculate statistical power and Type I error rates. The methodologies are directly motivated by the analysis of immunology data in 'Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial' (Parks et al. 2025) doi:10.1126/scitranslmed.ady6831.
Install
Health
- OK13 OKNow
- OK3 OK2026-10-07
Documentation
- Help pages
- 5 (1 internal)includes a package overview page
- Examples that run
- 50%2 run in a plain check · 2 only when donttest examples are enabled (R CMD check --as-cran)
- Exported functions with examples
- 100%
- Documented parameters
- 93%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Dependencies
Installing BBMBC adds 60 packages (33 with compiled code, 60 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, glmmTMB 5.2 MB.
Code & Tests
People & History
- 0.1.0Latest2026-10-07 · current release ·
3 days in CRAN's queue
Listed in CRAN's incoming queue from 2026-10-03 21:57 to 2026-10-07 06:45 UTC, in 16 readings. - RR 4.6.0 released · 2026-04-24
Package metadata
- First published
- 2026-10-07
- Total releases
- 1 / 1 yrs
- License
- MIT + file LICENSE OSI
- Minimum R
- ≥ 4.1.0
- Download size
- 8.9 KB
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