Improved False Positive Control of Gene-Permuting GSEA with Absolute Filtering
Overview
Gene-set enrichment analysis (GSEA) is popularly used to assess the enrichment of differential signal in a pre-defined gene-set without using a cutoff threshold for differential expression. The significance of enrichment is evaluated through sample- or gene-permutation method. Although the sample-permutation approach is highly recommended due to its good false positive control, we must use gene-permuting method if the number of samples is small. However, such gene-permuting GSEA (or preranked GSEA) generates a lot of false positive gene-sets as the inter-gene correlation in each gene set increases. These false positives can be successfully reduced by filtering with the one-tailed absolute GSEA results. This package provides a function that performs gene-permuting GSEA calculation with or without the absolute filtering. Without filtering, users can perform (original) two-tailed or one-tailed absolute GSEA.
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- RR 4.1.0 released · 2021-05-18
- archivedRemoved from CRAN2020-10-11check problems were not corrected in time
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- RR 3.5.0 released · 2018-04-23
- 1.5.12017-09-21 · diff ↗
- RR 3.4.0 released · 2017-04-21
- 1.52016-08-26 · diff ↗
- RR 3.3.0 released · 2016-05-03
- 1.2.12016-04-04 · diff ↗
- 1.22016-03-30 · diff ↗
- 1.02016-03-16 · diff ↗
- 0.12016-01-04
- RR 3.2.0 released · 2015-04-16
Package metadata
- First published
- 2016-01-04
- Total releases
- 6 / 10 yrs
- License
- GPL-2 OSI
- Bundled data
- 79 KB / 1 file
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