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tsdf

Two-/Three-Stage Designs for Phase 1&2 Clinical Trials

v1.1-8 · May 9, 2020 · GPL-2

Description

Calculate optimal Zhong's two-/three-stage Phase II designs (see Zhong (2012) <doi:10.1016/j.cct.2012.07.006>). Generate Target Toxicity decision table for Phase I dose-finding (two-/three-stage). This package also allows users to run dose-finding simulations based on customized decision table.

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r-devel-linux-x86_64-debian-clang NOTE
r-devel-linux-x86_64-debian-gcc NOTE
r-devel-linux-x86_64-fedora-clang NOTE
r-devel-linux-x86_64-fedora-gcc NOTE
r-devel-macos-arm64 NOTE
r-devel-windows-x86_64 NOTE
r-oldrel-macos-arm64 NOTE
r-oldrel-macos-x86_64 NOTE
r-oldrel-windows-x86_64 NOTE
r-patched-linux-x86_64 NOTE
r-release-linux-x86_64 NOTE
r-release-macos-arm64 NOTE
r-release-macos-x86_64 NOTE
r-release-windows-x86_64 NOTE
Check details (19 non-OK)
NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Wenchuan Guo <wguo1017@gmail.com>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Wenchuan",
                      family = "Guo",
                      role = c("aut", "cre"),
                      email = "wguo1017@gmail.com"),
               person(given = "Jianan",
                      family = "Hui",
                      role = "aut"),
               person(given = "Bob",
                      family = "Zhong",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-debian-clang

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Wenchuan Guo <wguo1017@gmail.com>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Wenchuan",
                      family = "Guo",
                      role = c("aut", "cre"),
                      email = "wguo1017@gmail.com"),
               person(given = "Jianan",
                      family = "Hui",
                      role = "aut"),
               person(given = "Bob",
                      family = "Zhong",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-devel-linux-x86_64-fedora-clang

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-devel-linux-x86_64-fedora-gcc

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-devel-macos-arm64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-devel-windows-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-oldrel-macos-arm64

LazyData

'LazyData' is specified without a 'data' directory
NOTE r-oldrel-macos-arm64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-oldrel-macos-x86_64

LazyData

'LazyData' is specified without a 'data' directory
NOTE r-oldrel-macos-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-oldrel-windows-x86_64

LazyData

'LazyData' is specified without a 'data' directory
NOTE r-oldrel-windows-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-patched-linux-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-release-linux-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-release-macos-arm64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-release-macos-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^
NOTE r-release-windows-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
       |                                                                                                                                                                                                ^
checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
       |                              ^
ch
...[truncated]...
 the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ^

Check History

NOTE 0 OK · 14 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Wenchuan Guo <wguo1017@gmail.com>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Wenchuan",
                      family = "Guo",
                      role = c("aut", "cre"),
              
...[truncated]...
.com"),
               person(given = "Jianan",
                      family = "Hui",
                      role = "aut"),
               person(given = "Bob",
                      family = "Zhong",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Wenchuan Guo <wguo1017@gmail.com>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Wenchuan",
                      family = "Guo",
                      role = c("aut", "cre"),
              
...[truncated]...
.com"),
               person(given = "Jianan",
                      family = "Hui",
                      role = "aut"),
               person(given = "Bob",
                      family = "Zhong",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-fedora-clang

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-devel-linux-x86_64-fedora-gcc

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-devel-macos-arm64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-devel-windows-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-patched-linux-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-release-linux-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-release-macos-arm64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-release-macos-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-release-windows-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-oldrel-macos-arm64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-oldrel-macos-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^
NOTE r-oldrel-windows-x86_64

Rd files

checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$
...[truncated]...
                                                                                                                                                                                                                                                         ^

Version History

new 1.1-8 Mar 10, 2026
updated 1.1-8 ← 1.1-7 diff May 8, 2020
updated 1.1-7 ← 1.1-4 diff May 31, 2019
updated 1.1-4 ← 1.1-2 diff Jan 10, 2018
new 1.1-2 Sep 5, 2017