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tlsR

Detection and Spatial Analysis of Tertiary Lymphoid Structures

v0.3.0 · Apr 23, 2026 · MIT + file LICENSE

Description

Fast, reproducible detection and quantitative analysis of tertiary lymphoid structures (TLS) in multiplexed tissue imaging. Implements Independent Component Analysis Trace (ICAT) index, local Ripley's K scanning, automated K Nearest Neighbor (KNN)-based TLS detection, and T-cell clusters identification as described in Amiryousefi et al. (2025) <doi:10.1101/2025.09.21.677465>.

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CRAN Check Status

13 OK
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r-devel-linux-x86_64-debian-clang OK
r-devel-linux-x86_64-debian-gcc OK
r-devel-linux-x86_64-fedora-clang OK
r-devel-linux-x86_64-fedora-gcc OK
r-devel-windows-x86_64 OK
r-oldrel-macos-arm64 OK
r-oldrel-macos-x86_64 OK
r-oldrel-windows-x86_64 OK
r-patched-linux-x86_64 OK
r-release-linux-x86_64 OK
r-release-macos-arm64 OK
r-release-macos-x86_64 OK
r-release-windows-x86_64 OK

Check History

OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026

Dependency Network

Dependencies Reverse dependencies dbscan fastICA FNN spatstat.explore spatstat.geom ggplot2 rlang tlsR

Version History

3 tracked
updated 0.3.0 ← 0.2.0 diff Apr 23, 2026
updated 0.2.0 ← 0.1.2 diff Apr 9, 2026
new 0.1.2 Mar 10, 2026

R Observatory began tracking this package on Mar 10, 2026; it first appeared on CRAN Dec 18, 2025. Releases before tracking aren’t shown.