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Single Cell Transcriptomics-Level Cytokine Activity Prediction and Estimation

v0.2.0 · Apr 16, 2025 · GPL (>= 2)

Description

Generates cell-level cytokine activity estimates using relevant information from gene sets constructed with the 'CytoSig' and the 'Reactome' databases and scored using the modified 'Variance-adjusted Mahalanobis (VAM)' framework for single-cell RNA-sequencing (scRNA-seq) data. 'CytoSig' database is described in: Jiang at al., (2021) <doi:10.1038/s41592-021-01274-5>. 'Reactome' database is described in: Gillespie et al., (2021) <doi:10.1093/nar/gkab1028>. The 'VAM' method is outlined in: Frost (2020) <doi:10.1093/nar/gkaa582>.

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CRAN Check Status

1 ERROR
13 OK
Show all 14 flavors
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r-devel-linux-x86_64-debian-clang OK
r-devel-linux-x86_64-debian-gcc OK
r-devel-linux-x86_64-fedora-clang OK
r-devel-linux-x86_64-fedora-gcc OK
r-devel-macos-arm64 OK
r-devel-windows-x86_64 OK
r-oldrel-macos-arm64 OK
r-oldrel-macos-x86_64 OK
r-oldrel-windows-x86_64 ERROR
r-patched-linux-x86_64 OK
r-release-linux-x86_64 OK
r-release-macos-arm64 OK
r-release-macos-x86_64 OK
r-release-windows-x86_64 OK
Check details (1 non-OK)
ERROR r-oldrel-windows-x86_64

re-building of vignette outputs

Error(s) in re-building vignettes:
--- re-building 'scaper-vignette-CytoSig.Rmd' using rmarkdown
Performing log-normalization
0%   10   20   30   40   50   60   70   80   90   100%
[----|----|----|----|----|----|----|----|----|----|
**************************************************|
Performing log-normalization
0%   10   20   30   40   50   60   70   80   90   100%
[----|----|----|----|----|----|----|----|----|----|
**************************************************|
! Package pdftex.def Error: File `ec02dfd7afbdbf34ecb6fab00197a77435fd302a.pdf'
 not found: using draft setting.

Error: processing vignette 'scaper-vignette-CytoSig.Rmd' failed with diagnostics:
LaTeX failed to compile D:/RCompile/CRANpkg/local/4.4/scaper.Rcheck/vign_test/scaper/vignettes/scaper-vignette-CytoSig.tex. See https://yihui.org/tinytex/r/#debugging for debugging tips. See scaper-vignette-CytoSig.log for more info.
--- failed re-building 'scaper-vignette-CytoSig.Rmd'

--- re-building 'scaper-vignette-Reactome.Rmd' using rmarkdown
Performing log-normalization
0%   10   20   30   40   50   60   70   80   90   100%
[----|----|----|----|----|----|----|----|----|----|
**************************************************|
! Package pdftex.def Error: File `f12efb46c3c7a4b66080cfdde11b7d9ebad2fad9.pdf'
 not found: using draft setting.

Error: processing vignette 'scaper-vignette-Reactome.Rmd' failed with diagnostics:
LaTeX failed to compile D:/RCompile/CRANpkg/local/4.4/scaper.Rcheck/vign_test/scaper/vignettes/scaper-vignette-Reactome.tex. See https://yihui.org/tinytex/r/#debugging for debugging tips. See scaper-vignette-Reactome.log for more info.
--- failed re-building 'scaper-vignette-Reactome.Rmd'

SUMMARY: processing the following files failed:
  'scaper-vignette-CytoSig.Rmd' 'scaper-vignette-Reactome.Rmd'

Error: Vignette re-building failed.
Execution halted

Check History

ERROR 13 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Mar 30, 2026
ERROR r-oldrel-windows-x86_64

re-building of vignette outputs

Error(s) in re-building vignettes:
--- re-building 'scaper-vignette-CytoSig.Rmd' using rmarkdown
Performing log-normalization
0%   10   20   30   40   50   60   70   80   90   100%
[----|----|----|----|----|----|----|----|----|----|
*****************
...[truncated]...
te-Reactome.log for more info.
--- failed re-building 'scaper-vignette-Reactome.Rmd'

SUMMARY: processing the following files failed:
  'scaper-vignette-CytoSig.Rmd' 'scaper-vignette-Reactome.Rmd'

Error: Vignette re-building failed.
Execution halted
OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026

Dependency Network

Dependencies Reverse dependencies magrittr xml2 stringr dplyr Seurat SeuratObject VAM scaper

Version History

new 0.2.0 Mar 10, 2026
updated 0.2.0 ← 0.1.0 diff Apr 15, 2025
new 0.1.0 Oct 18, 2023