Skip to content

pocrm

Dose Finding in Drug Combination Phase I Trials Using PO-CRM

v0.13 · Sep 8, 2021 · GPL-2
CRAN GitHub Mirror

Description

Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Downloads

282

Last 30 days

14781st

745

Last 90 days

2.9K

Last year

Trend: +7.2% (30d vs prior 30d)

CRAN Check Status

2 NOTE
12 OK
Show all 14 flavors
Flavor Status
r-devel-linux-x86_64-debian-clang NOTE
r-devel-linux-x86_64-debian-gcc NOTE
r-devel-linux-x86_64-fedora-clang OK
r-devel-linux-x86_64-fedora-gcc OK
r-devel-macos-arm64 OK
r-devel-windows-x86_64 OK
r-oldrel-macos-arm64 OK
r-oldrel-macos-x86_64 OK
r-oldrel-windows-x86_64 OK
r-patched-linux-x86_64 OK
r-release-linux-x86_64 OK
r-release-macos-arm64 OK
r-release-macos-x86_64 OK
r-release-windows-x86_64 OK
Check details (2 non-OK)
NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘"Brewer, Ben (arb5mt)" <arb5mt@virginia.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Nolan", "A."),
                      family = "Wages",
                      role = "aut"),
               person(family = "\"Brewer",
                      role = "cre"),
               person(family = "Ben\"",
                      role = "cre",
                      email = "arb5mt@virginia.edu",
                      comment = "arb5mt"))
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘"Brewer, Ben (arb5mt)" <arb5mt@virginia.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Nolan", "A."),
                      family = "Wages",
                      role = "aut"),
               person(family = "\"Brewer",
                      role = "cre"),
               person(family = "Ben\"",
                      role = "cre",
                      email = "arb5mt@virginia.edu",
                      comment = "arb5mt"))
as necessary.

Check History

NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘"Brewer, Ben (arb5mt)" <arb5mt@virginia.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Nolan", "A."),
                      family = "Wages",
                      role = "aut"),
    
...[truncated]...
person(family = "\"Brewer",
                      role = "cre"),
               person(family = "Ben\"",
                      role = "cre",
                      email = "arb5mt@virginia.edu",
                      comment = "arb5mt"))
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘"Brewer, Ben (arb5mt)" <arb5mt@virginia.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Nolan", "A."),
                      family = "Wages",
                      role = "aut"),
    
...[truncated]...
person(family = "\"Brewer",
                      role = "cre"),
               person(family = "Ben\"",
                      role = "cre",
                      email = "arb5mt@virginia.edu",
                      comment = "arb5mt"))
as necessary.

Dependency Network

Dependencies Reverse dependencies dfcrm nnet pocrm

Version History

new 0.13 Mar 10, 2026
updated 0.13 ← 0.12 diff Sep 7, 2021
updated 0.12 ← 0.11 diff Mar 14, 2019
updated 0.11 ← 0.9 diff Mar 2, 2018
updated 0.9 ← 0.8 diff Apr 9, 2015
updated 0.8 ← 0.7 diff Jul 23, 2014
updated 0.7 ← 0.6 diff Mar 10, 2014
updated 0.6 ← 0.5 diff Nov 25, 2013
updated 0.5 ← 0.4 diff May 1, 2013
new 0.4 Mar 27, 2013