pleioh2g
Estimation of Pleiotropic Heritability from Genome-Wide Association Studies (GWAS) Summary Statistics
v0.1.2
·
Mar 9, 2026
·
GPL-3
Description
Provides tools to compute unbiased pleiotropic heritability estimates of complex diseases from genome-wide association studies (GWAS) summary statistics. We estimate pleiotropic heritability from GWAS summary statistics by estimating the proportion of variance explained from an estimated genetic correlation matrix (Bulik-Sullivan et al. 2015 <doi:10.1038/ng.3406>) and employing a Monte-Carlo bias correction procedure to account for sampling noise in genetic correlation estimates.
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