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mectx

MEchanistic Clustering - Treatment eXposure Framework

v1.1.1 · May 11, 2026 · MIT + file LICENSE

Description

Implements the MEC-TX (MEchanistic Clustering - Treatment eXposure) framework for encoding, clustering, and survival analysis of real-world oncology treatment timelines. Provides functions for normalising medication records, computing treatment intervals, performing k-means clustering in PCA space, assigning line-of-therapy labels, and comparing survival outcomes across treatment groups. Designed for use with registry-based cohorts such as the ORIEN AVATAR dataset. Methods follow the digital-twin framework described in Dhrubo and Spakowicz (2026) <https://github.com/spakowiczlab/mec-tx>. treatment timelines using the MEC-TX digital-twin framework.

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OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 9, 2026
ERROR 12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Jun 8, 2026
ERROR r-devel-linux-x86_64-debian-gcc

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Installation failed.
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OK 8 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE May 12, 2026

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Dependency Network

Dependencies Reverse dependencies magrittr broom dplyr forcats ggnewscale ggplot2 patchwork purrr stringr survival tibble tidyr umap mectx

Version History

1 tracked
new 1.1.1 May 11, 2026