httkexamples
High-Throughput Toxicokinetics Examples
Description
High throughput toxicokinetics ("HTTK") is the combination of 1) chemical-specific in vitro measurements or in silico predictions and 2) generic mathematical models, to predict absorption, distribution, metabolism, and excretion by the body. HTTK methods have been described by Pearce et al. (2017) (<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>). Here we provide examples (vignettes) applying HTTK to solve various problems in bioinformatics, toxicology, and exposure science. In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>), whenever a new HTTK model is developed, the code to generate the figures evaluating that model is added as a new vignettte.
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Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | NOTE |
| r-oldrel-macos-x86_64 | NOTE |
| r-oldrel-windows-x86_64 | NOTE |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (4 non-OK)
DESCRIPTION meta-information
Packages listed in more than one of Depends, Imports, Suggests, Enhances: ‘ggpubr’ ‘ggforce’ A package should be listed in only one of these fields.
DESCRIPTION meta-information
Packages listed in more than one of Depends, Imports, Suggests, Enhances: ‘ggpubr’ ‘ggforce’ A package should be listed in only one of these fields.
installed package size
installed size is 5.8Mb
sub-directories of 1Mb or more:
data 2.0Mb
doc 3.3Mb
DESCRIPTION meta-information
Packages listed in more than one of Depends, Imports, Suggests, Enhances: 'ggpubr' 'ggforce' A package should be listed in only one of these fields.
Check History
NOTE 11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
DESCRIPTION meta-information
Packages listed in more than one of Depends, Imports, Suggests, Enhances: ‘ggpubr’ ‘ggforce’ A package should be listed in only one of these fields.
installed package size
installed size is 5.8Mb
sub-directories of 1Mb or more:
data 2.0Mb
doc 3.3Mb
DESCRIPTION meta-information
Packages listed in more than one of Depends, Imports, Suggests, Enhances: 'ggpubr' 'ggforce' A package should be listed in only one of these fields.