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Graphical Approach Optimal Sample Size

v1.0.0 · Aug 16, 2023 · GPL-3

Description

Graphical approach provides a useful framework for multiplicity adjustment in clinical trials with multiple endpoints. This package includes statistical methods to optimize sample size over initial weight and transition probability in a graphical approach under a common setting, which is to use marginal power for each endpoint in a trial design. See Zhang, F. and Gou, J. (2023). Sample size optimization for clinical trials using graphical approaches for multiplicity adjustment, Technical Report.

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Check History

OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026

Dependency Network

Dependencies Reverse dependencies GA mvtnorm graposas

Version History

new 1.0.0 Mar 10, 2026