dr4pl
Dose Response Data Analysis using the 4 Parameter Logistic (4pl) Model
Description
Models the relationship between dose levels and responses in a pharmacological experiment using the 4 Parameter Logistic model. Traditional packages on dose-response modelling such as 'drc' and 'nplr' often draw errors due to convergence failure especially when data have outliers or non-logistic shapes. This package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical principle. These methods are used as remedies to convergence failure problems. Gadagkar, S. R. and Call, G. B. (2015) <doi:10.1016/j.vascn.2014.08.006> Ritz, C. and Baty, F. and Streibig, J. C. and Gerhard, D. (2015) <doi:10.1371/journal.pone.0146021>.
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8334th
1.3K
Last 90 days
7.6K
Last year
Trend: +32.5% (30d vs prior 30d)
1
Last 30 days
25
Last 90 days
87
Last year
Trend: -90% (30d vs prior 30d)
5
Last 7 days
14
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1
All-time
autoCRAN-only: this name is served only by autoCRAN, so the count is exact.
CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | NOTE |
| r-oldrel-macos-x86_64 | NOTE |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
Rd files
checkRd: (-1) confint.dr4pl.Rd:49: Escaped LaTeX specials: \& checkRd: (-1) gof-dr4pl.Rd:40: Escaped LaTeX specials: \& checkRd: (-1) vcov.dr4pl.Rd:61: Escaped LaTeX specials: \&
Rd files
checkRd: (-1) confint.dr4pl.Rd:49: Escaped LaTeX specials: \& checkRd: (-1) gof-dr4pl.Rd:40: Escaped LaTeX specials: \& checkRd: (-1) vcov.dr4pl.Rd:61: Escaped LaTeX specials: \&
Check History
NOTE 8 OK · 6 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
Rd files
checkRd: (-1) confint.dr4pl.Rd:49: Escaped LaTeX specials: \& checkRd: (-1) gof-dr4pl.Rd:40: Escaped LaTeX specials: \& checkRd: (-1) vcov.dr4pl.Rd:61: Escaped LaTeX specials: \&
Rd files
checkRd: (-1) confint.dr4pl.Rd:49: Escaped LaTeX specials: \& checkRd: (-1) gof-dr4pl.Rd:40: Escaped LaTeX specials: \& checkRd: (-1) vcov.dr4pl.Rd:61: Escaped LaTeX specials: \&
Rd files
checkRd: (-1) confint.dr4pl.Rd:49: Escaped LaTeX specials: \& checkRd: (-1) gof-dr4pl.Rd:40: Escaped LaTeX specials: \& checkRd: (-1) vcov.dr4pl.Rd:61: Escaped LaTeX specials: \&
Rd files
checkRd: (-1) confint.dr4pl.Rd:49: Escaped LaTeX specials: \& checkRd: (-1) gof-dr4pl.Rd:40: Escaped LaTeX specials: \& checkRd: (-1) vcov.dr4pl.Rd:61: Escaped LaTeX specials: \&
Rd files
checkRd: (-1) confint.dr4pl.Rd:49: Escaped LaTeX specials: \& checkRd: (-1) gof-dr4pl.Rd:40: Escaped LaTeX specials: \& checkRd: (-1) vcov.dr4pl.Rd:61: Escaped LaTeX specials: \&
Rd files
checkRd: (-1) confint.dr4pl.Rd:49: Escaped LaTeX specials: \& checkRd: (-1) gof-dr4pl.Rd:40: Escaped LaTeX specials: \& checkRd: (-1) vcov.dr4pl.Rd:61: Escaped LaTeX specials: \&
Code
Structure
Lines of code
5,817
Files
95
Compiled share
0%
Has compiled src
No
Language breakdown
API
Exported functions
13
Internal functions
82
Recent export changes
Testing & CI
Has tests
Yes
Test-to-code ratio
0.13
testthat edition
–
CI present
No
CI type
[]
PR gated
No
Docs
Return-value doc rate
90%
\dontrun example ratio
3.7%
Roxygen coverage
100%
Has pkgdown
No
NEWS present
Yes
Health & Security signals
Informational signals; not verdicts.
on.exit coverage
–
Unsafe pattern score
0
Dep constraint coverage
0%
Secret pattern count
0
Bundled 3rd-party code
2 items
Portability & License
Min R version
3.1.0
System requirements
–
C++ standard
–
License
GPL (>= 2)
License flags
SPDX valid, OSI approved
History
Versions
9
First release
2017-10-22
Latest release
2021-08-17
Avg cadence
116 days
Cold removal rate
100%
Dep drift
8
LOC over versions
Per-file churn detail lives in the source pipeline: https://github.com/r-observatory/cran-code-metrics.