countland
Analysis of Biological Count Data, Especially from Single-Cell RNA-Seq
Description
A set of functions for applying a restricted linear algebra to the analysis of count-based data. See the accompanying preprint manuscript: "Normalizing need not be the norm: count-based math for analyzing single-cell data" Church et al (2022) <doi:10.1101/2022.06.01.494334> This tool is specifically designed to analyze count matrices from single cell RNA sequencing assays. The tools implement several count-based approaches for standard steps in single-cell RNA-seq analysis, including scoring genes and cells, comparing cells and clustering, calculating differential gene expression, and several methods for rank reduction. There are many opportunities for further optimization that may prove useful in the analysis of other data. We provide the source code freely available at <https://github.com/shchurch/countland> and encourage users and developers to fork the code for their own purposes.
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CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check History
OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 9, 2026
ERROR 12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Jun 8, 2026
examples
Running examples in ‘countland-Ex.R’ failed
The error most likely occurred in:
> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: Cluster
> ### Title: Perform spectral clustering on dot products.
> ### Aliases: Cluster
>
> ### **
...[truncated]...
, package = "countland", mustWork = TRUE)
> gold.data <- Seurat::Read10X(data.dir = gold_path)
Error in loadNamespace(x) : there is no package called ‘Seurat’
Calls: loadNamespace -> withRestarts -> withOneRestart -> doWithOneRestart
Execution halted
OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Apr 10, 2026
ERROR 13 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Apr 9, 2026
examples
Running examples in ‘countland-Ex.R’ failed
The error most likely occurred in:
> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: Cluster
> ### Title: Perform spectral clustering on dot products.
> ### Aliases: Cluster
>
> ### **
...[truncated]...
, package = "countland", mustWork = TRUE)
> gold.data <- Seurat::Read10X(data.dir = gold_path)
Error in loadNamespace(x) : there is no package called ‘Seurat’
Calls: loadNamespace -> withRestarts -> withOneRestart -> doWithOneRestart
Execution halted