SubtypeDrug
Prioritization of Candidate Cancer Subtype Specific Drugs
Description
A systematic biology tool was developed to prioritize cancer subtype-specific drugs by integrating genetic perturbation, drug action, biological pathway, and cancer subtype. The capabilities of this tool include inferring patient-specific subpathway activity profiles in the context of gene expression profiles with subtype labels, calculating differentially expressed subpathways based on cultured human cells treated with drugs in the 'cMap' (connectivity map) database, prioritizing cancer subtype specific drugs according to drug-disease reverse association score based on subpathway, and visualization of results (Castelo (2013) <doi:10.1186/1471-2105-14-7>; Han et al (2019) <doi:10.1093/bioinformatics/btz894>; Lamb and Justin (2006) <doi:10.1126/science.1132939>). Please cite using <doi:10.1093/bioinformatics/btab011>.
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CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | ERROR |
| r-oldrel-windows-x86_64 | ERROR |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (4 non-OK)
CRAN incoming feasibility
Maintainer: ‘Junwei Han <hanjunwei1981@163.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xudong",
family = "Han",
role = "aut"),
person(given = "Junwei",
family = "Han",
role = c("aut", "cre"),
email = "hanjunwei1981@163.com"),
person(given = "Chonghui",
family = "Liu",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Junwei Han <hanjunwei1981@163.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xudong",
family = "Han",
role = "aut"),
person(given = "Junwei",
family = "Han",
role = c("aut", "cre"),
email = "hanjunwei1981@163.com"),
person(given = "Chonghui",
family = "Liu",
role = "aut"))
as necessary.
package dependencies
Package required but not available: ‘ChemmineR’ See section ‘The DESCRIPTION file’ in the ‘Writing R Extensions’ manual.
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.5/SubtypeDrug.Rcheck/00install.out' for details.
Check History
ERROR 8 OK · 1 NOTE · 0 WARNING · 5 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Junwei Han <hanjunwei1981@163.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xudong",
family = "Han",
role = "aut"),
person(gi
...[truncated]...
family = "Han",
role = c("aut", "cre"),
email = "hanjunwei1981@163.com"),
person(given = "Chonghui",
family = "Liu",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Junwei Han <hanjunwei1981@163.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xudong",
family = "Han",
role = "aut"),
person(gi
...[truncated]...
family = "Han",
role = c("aut", "cre"),
email = "hanjunwei1981@163.com"),
person(given = "Chonghui",
family = "Liu",
role = "aut"))
as necessary.
package dependencies
Package required but not available: ‘ChemmineR’ See section ‘The DESCRIPTION file’ in the ‘Writing R Extensions’ manual.
package dependencies
Package required but not available: ‘ChemmineR’ See section ‘The DESCRIPTION file’ in the ‘Writing R Extensions’ manual.
package dependencies
Package required but not available: ‘ChemmineR’ See section ‘The DESCRIPTION file’ in the ‘Writing R Extensions’ manual.
installed package size
installed size is 5.7Mb
sub-directories of 1Mb or more:
data 5.0Mb