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PopED

Population (and Individual) Optimal Experimental Design

v0.7.0 · Oct 7, 2024 · LGPL (>= 3)

Description

Optimal experimental designs for both population and individual studies based on nonlinear mixed-effect models. Often this is based on a computation of the Fisher Information Matrix. This package was developed for pharmacometric problems, and examples and predefined models are available for these types of systems. The methods are described in Nyberg et al. (2012) <doi:10.1016/j.cmpb.2012.05.005>, and Foracchia et al. (2004) <doi:10.1016/S0169-2607(03)00073-7>.

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CRAN Check Status

13 OK
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Flavor Status
r-devel-linux-x86_64-debian-clang OK
r-devel-linux-x86_64-debian-gcc OK
r-devel-linux-x86_64-fedora-clang OK
r-devel-linux-x86_64-fedora-gcc OK
r-devel-windows-x86_64 OK
r-oldrel-macos-arm64 OK
r-oldrel-macos-x86_64 OK
r-oldrel-windows-x86_64 OK
r-patched-linux-x86_64 OK
r-release-linux-x86_64 OK
r-release-macos-arm64 OK
r-release-macos-x86_64 OK
r-release-windows-x86_64 OK

Check History

OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Apr 22, 2026
ERROR 13 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Apr 18, 2026
ERROR r-devel-windows-x86_64

re-building of vignette outputs

Error(s) in re-building vignettes:
--- re-building 'examples.Rmd' using rmarkdown

Quitting from examples.Rmd:289-307 [unnamed-chunk-12]
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
<error/rlang_error>
Error in `so
...[truncated]...
--- failed re-building 'examples.Rmd'

--- re-building 'intro-poped.Rmd' using rmarkdown
--- finished re-building 'intro-poped.Rmd'

SUMMARY: processing the following file failed:
  'examples.Rmd'

Error: Vignette re-building failed.
Execution halted
OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026

Reverse Dependencies (3)

imports

Dependency Network

Dependencies Reverse dependencies ggplot2 MASS mvtnorm dplyr codetools magrittr boot purrr stringr tibble gtools ncappc babelmixr2 nlmixr2save PopED

Version History

12 tracked
new 0.7.0 Mar 10, 2026
updated 0.7.0 ← 0.6.0 diff Oct 6, 2024
updated 0.6.0 ← 0.5.0 diff May 20, 2021
updated 0.5.0 ← 0.4.0 diff Jun 12, 2020
updated 0.4.0 ← 0.3.2 diff Sep 9, 2018
updated 0.3.2 ← 0.3.1 diff Dec 11, 2016
updated 0.3.1 ← 0.3.0 diff Oct 18, 2016
updated 0.3.0 ← 0.2.0 diff Dec 28, 2015
updated 0.2.0 ← 0.1.2 diff Mar 19, 2015
updated 0.1.2 ← 0.1.1 diff Nov 18, 2014
updated 0.1.1 ← 0.1.0 diff May 26, 2014
new 0.1.0 Apr 27, 2014