MetaSubtract
Subtracting Summary Statistics of One or more Cohorts from Meta-GWAS Results
Description
If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. The validation cohort needs to be independent from the meta-Genome-Wide-Association-Study (meta-GWAS) results. 'MetaSubtract' will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. It can also handle different meta-analysis methods. It can be used for whole GWAS, but also for a limited set of genetic markers. See for application: Nolte I.M. et al. (2017); <doi: 10.1038/ejhg.2017.50>.
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CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Ilja M. Nolte <i.m.nolte@umcg.nl>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = c("Ilja", "M."),
family = "Nolte",
role = c("aut", "cre"),
email = "i.m.nolte@umcg.nl")
as necessary.
CRAN incoming feasibility
Maintainer: ‘Ilja M. Nolte <i.m.nolte@umcg.nl>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = c("Ilja", "M."),
family = "Nolte",
role = c("aut", "cre"),
email = "i.m.nolte@umcg.nl")
as necessary.
Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Ilja M. Nolte <i.m.nolte@umcg.nl>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = c("Ilja", "M."),
family = "Nolte",
role = c("aut", "cre"),
email = "i.m.nolte@umcg.nl")
as necessary.
CRAN incoming feasibility
Maintainer: ‘Ilja M. Nolte <i.m.nolte@umcg.nl>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = c("Ilja", "M."),
family = "Nolte",
role = c("aut", "cre"),
email = "i.m.nolte@umcg.nl")
as necessary.