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MedZIsc

Statistical Framework for Co-Mediators of Zero-Inflated Single-Cell Data

v0.0.4 · Jul 16, 2025 · GPL-3

Description

A causal mediation framework for single-cell data that incorporates two key features ('MedZIsc', pronounced Magics): (1) zero-inflation using beta regression and (2) overdispersed expression counts using negative binomial regression. This approach also includes a screening step based on penalized and marginal models to handle high-dimensionality. Full methodological details are available in our recent preprint by Ahn S and Li Z (2025) <doi:10.48550/arXiv.2505.22986>.

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Dependencies Reverse dependencies MASS betareg glmnet MedZIsc

Version History

1 tracked
new 0.0.4 Mar 10, 2026

R Observatory began tracking this package on Mar 10, 2026; it first appeared on CRAN Jul 16, 2025. Releases before tracking aren’t shown.