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LTFHPlus

Implementation of LT-FH++

v2.2.0 · Nov 17, 2025 · GPL-3

Description

Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <doi:10.1016/j.ajhg.2022.01.009> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <https://www.nature.com/articles/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.

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r-patched-linux-x86_64 OK
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Check History

OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026

Dependency Network

Dependencies Reverse dependencies batchmeans dplyr future.apply future purrr Rcpp rlang stringr tibble tmvtnorm tidyselect igraph xgboost tidyr ggplot2 LTFHPlus

Version History

new 2.2.0 Mar 10, 2026
updated 2.2.0 ← 2.1.4 diff Nov 16, 2025
updated 2.1.4 ← 2.1.3 diff May 25, 2025
updated 2.1.3 ← 2.1.2 diff May 12, 2025
updated 2.1.2 ← 2.1.1 diff Nov 21, 2024
new 2.1.1 Feb 11, 2024