Keyboard
Bayesian Designs for Early Phase Clinical Trials
Description
We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) <doi:10.1158/1078-0432.CCR-17-0220>, Li DH, Whitmore JB, Guo W, Ji Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>, Liu S, Johnson VE (2016) <doi:10.1093/biostatistics/kxv040>, Zhou Y, Lee JJ, Yuan Y (2019) <doi:10.1002/sim.8475>, Pan H, Lin R, Yuan Y (2020) <doi:10.1016/j.cct.2020.105972>). The 'Keyboard' package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials. For more details about how to use this packge, please refer to Li C, Sun H, Cheng C, Tang L, and Pan H. (2022) "A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs". Manuscript submitted for publication.
Downloads
323
Last 30 days
13999th
723
Last 90 days
2.7K
Last year
Trend: +91.1% (30d vs prior 30d)
0
Last 30 days
23
Last 90 days
94
Last year
Trend: -100% (30d vs prior 30d)
3
Last 7 days
14
Last 30 days
0
All-time
autoCRAN-only: this name is served only by autoCRAN, so the count is exact.
CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
email = "xiaomeng.yuan@stjude.org"),
person(given = "Chen",
family = "Li",
role = "aut"),
person(given = "Hongying",
family = "Sun",
role = "aut"),
person(given = "Li",
family = "Tang",
role = "aut"),
person(given = "Haitao",
family = "Pan",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
email = "xiaomeng.yuan@stjude.org"),
person(given = "Chen",
family = "Li",
role = "aut"),
person(given = "Hongying",
family = "Sun",
role = "aut"),
person(given = "Li",
family = "Tang",
role = "aut"),
person(given = "Haitao",
family = "Pan",
role = "aut"))
as necessary.
Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
...[truncated]...
= "aut"),
person(given = "Li",
family = "Tang",
role = "aut"),
person(given = "Haitao",
family = "Pan",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
...[truncated]...
= "aut"),
person(given = "Li",
family = "Tang",
role = "aut"),
person(given = "Haitao",
family = "Pan",
role = "aut"))
as necessary.
Code
Structure
Lines of code
6,272
Files
36
Compiled share
0%
Has compiled src
No
Language breakdown
API
Exported functions
16
Internal functions
0
Recent export changes
Testing & CI
Has tests
No
Test-to-code ratio
0.00
testthat edition
–
CI present
No
CI type
[]
PR gated
No
Docs
Return-value doc rate
100%
\dontrun example ratio
50%
Roxygen coverage
100%
Has pkgdown
No
NEWS present
No
Health & Security signals
Informational signals; not verdicts.
on.exit coverage
100%
Unsafe pattern score
0
Dep constraint coverage
25%
Secret pattern count
0
Bundled 3rd-party code
2 items
Portability & License
Min R version
3.4.0
System requirements
–
C++ standard
–
License
GPL-2
License flags
SPDX valid, OSI approved
History
Versions
2
First release
2020-07-07
Latest release
2022-08-11
Avg cadence
765 days
Cold removal rate
100%
Dep drift
1
LOC over versions
Per-file churn detail lives in the source pipeline: https://github.com/r-observatory/cran-code-metrics.