HybridDesign

Hybrid Design for Phase I Dose-Finding Studies

v1.0 · Dec 15, 2022 · GPL-3

Description

The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.

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r-devel-linux-x86_64-debian-clang	OK	57.8s
r-devel-linux-x86_64-debian-gcc	OK	44.6s
r-devel-linux-x86_64-fedora-clang	OK	86.4s
r-devel-linux-x86_64-fedora-gcc	OK	83.2s
r-devel-macos-arm64	OK	19s
r-devel-windows-x86_64	OK	71s
r-oldrel-macos-arm64	OK
r-oldrel-macos-x86_64	OK	52s
r-oldrel-windows-x86_64	OK	82s
r-patched-linux-x86_64	OK	53.9s
r-release-linux-x86_64	OK	52.8s
r-release-macos-arm64	OK
r-release-macos-x86_64	OK	62s
r-release-windows-x86_64	OK	69s

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OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026

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new 1.0 Mar 10, 2026