DTEBOP2

Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes

v1.0.3 · May 9, 2025 · GPL-3

Description

Implements a Bayesian Optimal Phase II design (DTE-BOP2) for trials with delayed treatment effects, particularly relevant to immunotherapy studies where treatment benefits may emerge after a delay. The method builds upon the BOP2 framework and incorporates uncertainty in the delay timepoint through a truncated gamma prior, informed by expert knowledge or default settings. Supports two-arm trial designs with functionality for sample size determination, interim and final analyses, and comprehensive simulation under various delay and design scenarios. Ensures rigorous type I and II error control while improving trial efficiency and power when the delay effect is present. A manuscript describing the methodology is under development and will be formally referenced upon publication.

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CRAN Check Status

13 OK

Show all 13 flavors

Flavor	Status	Time
r-devel-linux-x86_64-debian-clang	OK	550s
r-devel-linux-x86_64-debian-gcc	OK	313.6s
r-devel-linux-x86_64-fedora-clang	OK	935s
r-devel-linux-x86_64-fedora-gcc	OK	930s
r-devel-windows-x86_64	OK	441s
r-oldrel-macos-arm64	OK
r-oldrel-macos-x86_64	OK	543s
r-oldrel-windows-x86_64	OK	674s
r-patched-linux-x86_64	OK	518.8s
r-release-linux-x86_64	OK
r-release-macos-arm64	OK	111s
r-release-macos-x86_64	OK	546s
r-release-windows-x86_64	OK	449s

Check History

OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 9, 2026

ERROR 12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Jun 8, 2026

ERROR r-devel-linux-x86_64-debian-gcc

re-building of vignette outputs

Error(s) in re-building vignettes:
  ...
--- re-building ‘DTEBOP2.Rmd’ using rmarkdown

Quitting from DTEBOP2.Rmd:189-234 [setup]
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
<error/rlang_error>
Error in `library()
...[truncated]...
sing vignette 'DTEBOP2.Rmd' failed with diagnostics:
there is no package called 'reconstructKM'
--- failed re-building ‘DTEBOP2.Rmd’

SUMMARY: processing the following file failed:
  ‘DTEBOP2.Rmd’

Error: Vignette re-building failed.
Execution halted

OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026