Description
Dose Titration Algorithm Tuning (DTAT) is a methodologic framework allowing dose individualization to be conceived as a continuous learning process that begins in early-phase clinical trials and continues throughout drug development, on into clinical practice. This package includes code that researchers may use to reproduce or extend key results of the DTAT research programme, plus tools for trialists to design and simulate a '3+3/PC' dose-finding study. Please see Norris (2017a) <doi:10.12688/f1000research.10624.3> and Norris (2017c) <doi:10.1101/240846>.
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CRAN Check Status
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| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | ERROR |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (1 non-OK)
re-building of vignette outputs
Error(s) in re-building vignettes: --- re-building 'Designing-33PC.Rmd' using rmarkdown --- finished re-building 'Designing-33PC.Rmd' --- re-building 'dtat.Rmd' using rmarkdown ! Package pdftex.def Error: File `52d53f84fdf1895479263805a7bfc6426ef06547.pdf' not found: using draft setting. Error: processing vignette 'dtat.Rmd' failed with diagnostics: LaTeX failed to compile D:/RCompile/CRANpkg/local/4.4/DTAT.Rcheck/vign_test/DTAT/vignettes/dtat.tex. See https://yihui.org/tinytex/r/#debugging for debugging tips. See dtat.log for more info. --- failed re-building 'dtat.Rmd' SUMMARY: processing the following file failed: 'dtat.Rmd' Error: Vignette re-building failed. Execution halted
Check History
ERROR 13 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Mar 30, 2026
re-building of vignette outputs
Error(s) in re-building vignettes: --- re-building 'Designing-33PC.Rmd' using rmarkdown --- finished re-building 'Designing-33PC.Rmd' --- re-building 'dtat.Rmd' using rmarkdown ! Package pdftex.def Error: File `52d53f84fdf1895479263805a7bfc6426ef065 ...[truncated]... /dtat.tex. See https://yihui.org/tinytex/r/#debugging for debugging tips. See dtat.log for more info. --- failed re-building 'dtat.Rmd' SUMMARY: processing the following file failed: 'dtat.Rmd' Error: Vignette re-building failed. Execution halted